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Gene Review

CkIalpha  -  Casein kinase Ialpha

Drosophila melanogaster

Synonyms: CG2028, CK I, CK1, CK1a, CK1alpha, ...
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Disease relevance of CkIalpha


High impact information on CkIalpha

  • This was first shown in Drosophila with the characterization of Doubletime (Dbt), a homologue of vertebrate casein kinase Iepsilon [2].
  • CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop [3].
  • These results indicate that CKI functions as a negative regulator of Wg/Arm signaling [4].
  • Overexpression of CKIalpha induced hyper-phosphorylation of both Arm and Dishevelled in S2R+ cells and, conversely, CKIalpha-RNAi reduced the amount of hyper-modified forms [4].
  • His-tagged Arm was phosphorylated by CKIalpha in vitro on a set of serine and threonine residues that are also phosphorylated by Zeste-white 3 [4].

Biological context of CkIalpha


Anatomical context of CkIalpha


Associations of CkIalpha with chemical compounds


Enzymatic interactions of CkIalpha


Regulatory relationships of CkIalpha


Other interactions of CkIalpha


Analytical, diagnostic and therapeutic context of CkIalpha


  1. Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures. Alcalay, N.I., Brantley, J.G., Sharma, M., Gooch, J.L., Vanden Heuvel, G.B. Dev. Dyn. (2007) [Pubmed]
  2. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Ko, H.W., Jiang, J., Edery, I. Nature (2002) [Pubmed]
  3. CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. He, Q., Cha, J., He, Q., Lee, H.C., Yang, Y., Liu, Y. Genes Dev. (2006) [Pubmed]
  4. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. Yanagawa, S., Matsuda, Y., Lee, J.S., Matsubayashi, H., Sese, S., Kadowaki, T., Ishimoto, A. EMBO J. (2002) [Pubmed]
  5. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Jia, J., Zhang, L., Zhang, Q., Tong, C., Wang, B., Hou, F., Amanai, K., Jiang, J. Dev. Cell (2005) [Pubmed]
  6. Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I. Preuss, F., Fan, J.Y., Kalive, M., Bao, S., Schuenemann, E., Bjes, E.S., Price, J.L. Mol. Cell. Biol. (2004) [Pubmed]
  7. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Zilian, O., Frei, E., Burke, R., Brentrup, D., Gutjahr, T., Bryant, P.J., Noll, M. Development (1999) [Pubmed]
  8. The casein kinase I family: roles in morphogenesis. McKay, R.M., Peters, J.M., Graff, J.M. Dev. Biol. (2001) [Pubmed]
  9. Constitutive expression and delayed light response of casein kinase Iepsilon and Idelta mRNAs in the mouse suprachiasmatic nucleus. Ishida, Y., Yagita, K., Fukuyama, T., Nishimura, M., Nagano, M., Shigeyoshi, Y., Yamaguchi, S., Komori, T., Okamura, H. J. Neurosci. Res. (2001) [Pubmed]
  10. Casein Kinases I of the Silkworm, Bombyx mori: Their Possible Roles in Circadian Timing and Developmental Determination. Trang, l.e. .T.D., Sehadova, H., Ichihara, N., Iwai, S., Mita, K., Takeda, M. J. Biol. Rhythms (2006) [Pubmed]
  11. The circadian clock-containing photoreceptor cells in Xenopus laevis express several isoforms of casein kinase I. Constance, C.M., Fan, J.Y., Preuss, F., Green, C.B., Price, J.L. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  12. Molecular modeling of insect ferritins. Pham, D.Q. In Silico Biol. (Gedrukt) (2002) [Pubmed]
  13. Casein kinase I in the Mammalian circadian clock. Eide, E.J., Kang, H., Crapo, S., Gallego, M., Virshup, D.M. Meth. Enzymol. (2005) [Pubmed]
  14. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Matsubayashi, H., Sese, S., Lee, J.S., Shirakawa, T., Iwatsubo, T., Tomita, T., Yanagawa, S. Mol. Cell. Biol. (2004) [Pubmed]
  15. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Jia, J., Tong, C., Wang, B., Luo, L., Jiang, J. Nature (2004) [Pubmed]
  16. Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Strutt, H., Price, M.A., Strutt, D. Curr. Biol. (2006) [Pubmed]
  17. The casein kinase 1 alpha gene of Drosophila melanogaster is developmentally regulated and the kinase activity of the protein induced by DNA damage. Santos, J.A., Logarinho, E., Tapia, C., Allende, C.C., Allende, J.E., Sunkel, C.E. J. Cell. Sci. (1996) [Pubmed]
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