Disease relevance of CKI1

• Casein kinase activity was detected in the soluble fraction of Escherichia coli strains expressing the CKI1 protein [1].

High impact information on CKI1

• A gene, CKI1, which was tagged in four of the five mutants and induced typical cytokinin responses after introduction and overexpression in plants, was cloned [2].
• These results suggest that CKI1 is involved in cytokinin signal transduction, possibly as a cytokinin receptor [2].
• Cytokinin-Independent 1 (CKI1) belongs to a group of putative plant histidine kinases whose members do not appear to act as ethylene receptors [3].
• The deduced protein structure, combined with the observation that Arabidopsis callus cultures overexpressing CKI1 exhibit a "cytokinin-independent" cell division and greening phenotype, led to the hypothesis that CKI1 is involved in cytokinin signaling, perhaps acting as a cytokinin receptor [3].
• Two other hybrid-type histidine kinases, CKI1 and ATHK1, are implicated in cytokinin signaling and osmosensing processes, respectively [4].

Biological context of CKI1

• One full-length clone, designated CKI1, contained an open reading frame of 1371 bp encoding a protein of 51,949 D with an isoelectric point of 9 [1].

Associations of CKI1 with chemical compounds

• Like several recombinant CKI isoforms from yeast, CKI1 was able to phosphorylate tyrosine-containing acidic polymers [1].

References