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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CTTNBP2  -  cortactin binding protein 2

Homo sapiens

Synonyms: C7orf8, CORTBP2, CortBP2, Cortactin-binding protein 2, KIAA1758, ...
 
 
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High impact information on CTTNBP2

  • We investigated in different human cell types nuclear positioning and transcriptional regulation of the functionally unrelated genes GASZ, CFTR, and CORTBP2, mapping to adjacent loci on human chromosome 7q31 [1].
  • In addition to being a positional candidate for AUTS1, CORTBP2 was expressed at highest levels in the brain, as shown by northern blot analysis [2].
  • Subsequent mutation analysis of CORTBP2 in 90 autistic patients identified two polymorphisms, including a leucine to valine change caused by a T to G substitution in exon 15 [2].
  • The putative Orf4 of broad-host-range conjugative plasmid R446 could Be related to the H-NS family of bacterial nucleoid-associated proteins [3].
  • We have performed a computational analysis of the iml determinant of IncM plasmid R446 and found that a potential polypeptide (Orf4) shows similarity to the H-NS family of nucleoid-associated modulators of gene expression [3].
 

Biological context of CTTNBP2

  • Orf4 is adjacent and upstream of Orf5, a potential polypeptide related to the Hha/YmoA/RmoA family of proteins which modulate bacterial virulence expression (Hha and YmoA) and R100 transfer (RmoA) in response to environmental conditions [3].

References

  1. Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. Zink, D., Amaral, M.D., Englmann, A., Lang, S., Clarke, L.A., Rudolph, C., Alt, F., Luther, K., Braz, C., Sadoni, N., Rosenecker, J., Schindelhauer, D. J. Cell Biol. (2004) [Pubmed]
  2. Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. Cheung, J., Petek, E., Nakabayashi, K., Tsui, L.C., Vincent, J.B., Scherer, S.W. Genomics (2001) [Pubmed]
  3. The putative Orf4 of broad-host-range conjugative plasmid R446 could Be related to the H-NS family of bacterial nucleoid-associated proteins. Nieto, J.M., Juárez, A. Plasmid (1999) [Pubmed]
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