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Gene Review:

Synj2 - synaptojanin 2

Rattus norvegicus

Synonyms: Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2, Synaptojanin-2

Mochizuki, Y. et al., Nemoto, Y. et al., Nemoto, Y. et al., Kudo, M. et al.

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High impact information on Synj2

We have previously identified synaptojanin 1, a phosphoinositide phosphatase predominantly expressed in the nervous system, and synaptojanin 2, a broadly expressed isoform [1].
This enzyme hydrolyzed phosphate at the D-5 position of inositol 1,4,5-trisphosphate, inositol 1,3,4, 5-tetrakisphosphate, and phosphatidylinositol 4,5-bisphosphate, consistent with the substrate specificity of type II 5-phosphatase, OCRL, synaptojanin and synaptojanin 2, already characterized 5-phosphatases [2].
Expression of synaptojanin 2 in COS7 cells produced a 140-kDa protein with inositol 5'-phosphatase actvity [3].
We have now identified and characterized a novel form of synaptojanin, synaptojanin 2, which has a broader tissue distribution [3].
Synaptojanin 2 mRNA was first detected in neurons of the olfactory bulb, the cerebral cortex, the hippocampus, and the cerebellar cortex on early postnatal days [4].

References

Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto, Y., Wenk, M.R., Watanabe, M., Daniell, L., Murakami, T., Ringstad, N., Yamada, H., Takei, K., De Camilli, P. J. Biol. Chem. (2001) [Pubmed]
Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. Mochizuki, Y., Takenawa, T. J. Biol. Chem. (1999) [Pubmed]
Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. Nemoto, Y., Arribas, M., Haffner, C., DeCamilli, P. J. Biol. Chem. (1997) [Pubmed]
Localization of mRNAs for synaptojanin isoforms in the brain of developing and mature rats. Kudo, M., Saito, S., Sakagami, H., Suzaki, H., Kondo, H. Brain Res. Mol. Brain Res. (1999) [Pubmed]

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SYNJ2	Bos taurus
SYNJ2	Canis lupus familiaris
SYNJ2	Gallus gallus
SYNJ2	Homo sapiens
Synj2	Mus musculus
LOC463094	Pan troglodytes
synj2	Xenopus (Silurana) tropicalis

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