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Gene Review

Synj1  -  synaptojanin 1

Rattus norvegicus

Synonyms: Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1, Synaptojanin-1
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  1. A presynaptic inositol-5-phosphatase. McPherson, P.S., Garcia, E.P., Slepnev, V.I., David, C., Zhang, X., Grabs, D., Sossin, W.S., Bauerfeind, R., Nemoto, Y., De Camilli, P. Nature (1996) [Pubmed]
  2. Identification of the major synaptojanin-binding proteins in brain. de Heuvel, E., Bell, A.W., Ramjaun, A.R., Wong, K., Sossin, W.S., McPherson, P.S. J. Biol. Chem. (1997) [Pubmed]
  3. PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. Wenk, M.R., Pellegrini, L., Klenchin, V.A., Di Paolo, G., Chang, S., Daniell, L., Arioka, M., Martin, T.F., De Camilli, P. Neuron (2001) [Pubmed]
  4. Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. Nemoto, Y., De Camilli, P. EMBO J. (1999) [Pubmed]
  5. Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. Nemoto, Y., Arribas, M., Haffner, C., DeCamilli, P. J. Biol. Chem. (1997) [Pubmed]
  6. Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. Ringstad, N., Nemoto, Y., De Camilli, P. J. Biol. Chem. (2001) [Pubmed]
  7. Tissue-specific alternative splicing generates two synaptojanin isoforms with differential membrane binding properties. Ramjaun, A.R., McPherson, P.S. J. Biol. Chem. (1996) [Pubmed]
  8. Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals. Bauerfeind, R., Takei, K., De Camilli, P. J. Biol. Chem. (1997) [Pubmed]
  9. Intraneuronal trafficking and distribution of amphiphysin and synaptojanin in the rat peripheral nervous system and the spinal cord. Li, J.Y., De Camilli, P., Dahlström, A. Eur. J. Neurosci. (1997) [Pubmed]
  10. The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. Cestra, G., Toomre, D., Chang, S., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate. Chung, J.K., Sekiya, F., Kang, H.S., Lee, C., Han, J.S., Kim, S.R., Bae, Y.S., Morris, A.J., Rhee, S.G. J. Biol. Chem. (1997) [Pubmed]
  12. Synaptojanin is the major constitutively active phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase in rodent brain. Woscholski, R., Finan, P.M., Radley, E., Totty, N.F., Sterling, A.E., Hsuan, J.J., Waterfield, M.D., Parker, P.J. J. Biol. Chem. (1997) [Pubmed]
  13. Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis. Qiao, Y., Yang, J.X., Zhang, X.D., Liu, Y., Zhang, J.C., Zong, S.D., Miao, S.Y., Wang, L.F., Koide, S.S. Cell Res. (2004) [Pubmed]
  14. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Ringstad, N., Nemoto, Y., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. Cousin, M.A., Tan, T.C., Robinson, P.J. J. Neurochem. (2001) [Pubmed]
  16. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. Mochizuki, Y., Takenawa, T. J. Biol. Chem. (1999) [Pubmed]
  17. Interaction of phospholipase C gamma 1 via its COOH-terminal SRC homology 2 domain with synaptojanin. Ahn, S.J., Han, S.J., Mo, H.J., Chung, J.K., Hong, S.H., Park, T.K., Kim, C.G. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  18. Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis. Praefcke, G.J., Ford, M.G., Schmid, E.M., Olesen, L.E., Gallop, J.L., Peak-Chew, S.Y., Vallis, Y., Babu, M.M., Mills, I.G., McMahon, H.T. EMBO J. (2004) [Pubmed]
  19. Localization of mRNAs for synaptojanin isoforms in the brain of developing and mature rats. Kudo, M., Saito, S., Sakagami, H., Suzaki, H., Kondo, H. Brain Res. Mol. Brain Res. (1999) [Pubmed]
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