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Kcnq1  -  potassium channel, voltage-gated KQT-like...

Rattus norvegicus

Synonyms: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Kcna9, Kvlqt1, Potassium voltage-gated channel subfamily KQT member 1, ...
 
 
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High impact information on Kcnq1

  • In addition, Kcne3, an auxiliary subunit for Kcnq1, was detected in the lateral membrane of crypt and surface cells in guinea pig distal colon [1].
  • Although immunofluorescence labeling with a Kcnq1 antibody supported the basolateral membrane presence in colonic epithelium of the guinea pig as well as the rat, the Kcnq1 K(+) channel is not an essential component for producing Cl(-) secretion [1].
  • Colonic mucosa from guinea pig and rat were fixed, sectioned, and then probed with antibodies to the K(+) channel proteins K(V)LQT1 (Kcnq1) and minK-related peptide 2 (MiRP2, Kcne3) [1].
  • EAG and Kcnq transcripts are prominent in several types of excitatory neurons in the cortex and hippocampus; however, only one of these channel components (erg1) was consistently expressed in inhibitory interneurons in these areas [2].
 

Analytical, diagnostic and therapeutic context of Kcnq1

References

  1. K+ channel KVLQT1 located in the basolateral membrane of distal colonic epithelium is not essential for activating Cl- secretion. Liao, T., Wang, L., Halm, S.T., Lu, L., Fyffe, R.E., Halm, D.R. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich, M.J., Machado, E., Rudy, B. J. Neurosci. (2001) [Pubmed]
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