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Kcnh2  -  potassium channel, voltage gated eag...

Rattus norvegicus

Synonyms: ERG-1, Eag-related protein 1, Erg, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, ...
 
 
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Psychiatry related information on Kcnh2

  • Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid [1].
 

High impact information on Kcnh2

 

Biological context of Kcnh2

  • In this first report of regulation by tyrosine phosphorylation we show that MLS-9 cells express transcripts for r-erg1 (rat homologue of HERG) and r-erg2, and an immunoreactive doublet was identified using an anti-HERG antibody [2].
  • The membrane depolarization by 1 microM E-4031 indicates the contribution of K(+) channels encoded by ERG1/KCNE2 to the resting membrane potential in stomach SMCs [5].
  • Repression of ERalpha-dependent transcription required the carboxyterminal and aminoterminal transactivation domains of Erg whereas the carboxyterminal AF-2 domain of ERalpha was necessary for repression of Erg activity [6].
 

Anatomical context of Kcnh2

  • Immunoelectron microscopy of atrial and ventricular myocytes showed that the ERG1 channel was primarily expressed in the transverse tubular system and its entrance, whereas KCNQ1 was detected in both the peripheral sarcolemma and in the T tubules [7].
  • Confocal immunofluorescence microscopy of atrial and ventricular cells revealed that whereas KCNQ1 labeling was detected in both the peripheral sarcolemma and a structure transversing the myocytes, ERG1 immunoreactivity was confined to the latter [7].
  • After co-expression of these mutants with the wild-type erg1, erg2, or erg3 in Chinese hamster ovary (CHO) cells no erg currents could be detected [8].
  • EAG and Kcnq transcripts are prominent in several types of excitatory neurons in the cortex and hippocampus; however, only one of these channel components (erg1) was consistently expressed in inhibitory interneurons in these areas [9].
  • Most of orally administered Erg and 7-DHC were excreted in feces and the remaining sterols were absorbed through intestine [10].
 

Associations of Kcnh2 with chemical compounds

  • Application of TRH induced a reduction of maximal erg conductance for all tested erg1 currents without effects on the voltage dependence of steady-state inactivation [11].
  • Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells [12].
  • Furthermore, the reversal of the effects of TRH, but not its ability to suppress r-ERG currents, was blocked if diacylglycerol generation was prevented by blocking phospholipase C activity with U-73122 [12].
  • NOC-18 and SNAP caused a decrease in the amplitude of slow-inactivating (IDR) and ether-à-go-go-related gene (ERG) hyperpolarization-evoked, deactivating K+ currents [13].
  • Metabolism of orally administered ergosterol (Erg) and 7-dehydrocholesterol (7-DHC) in rats and their vitamin D biological activity were investigated [10].
 

Other interactions of Kcnh2

  • The biochemical cascade linking activation of phospholipase C-coupled thyrotropin-releasing hormone (TRH) receptors to rat ERG (r-ERG) channel modulation was studied in situ using perforated-patch clamped adenohypophysial GH3 cells and pharmacological inhibitors [12].
  • Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release [14].
 

Analytical, diagnostic and therapeutic context of Kcnh2

  • The region-qualified multicell RT-PCR showed that ERG1/KCNE2 transcripts were expressed in rat stomach fundus and antrum SMCs and that KCNQ1/KCNE1 transcripts were expressed in antrum but not fundus [5].
  • Western blotting and immunocytochemical analyses indicate that ERG1 proteins were substantially expressed in both regions, whereas KCNE1 proteins were faintly expressed in antrum and not in fundus [5].
  • Neither increment of intestinal calcium absorption nor plasma calcium concentrations were observed by oral administration of Erg and 7-DHC to vitamin D-deficient rats [10].

References

  1. Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid. Yin, S., Guan, Z., Tang, Y., Zhao, J., Hong, J., Zhang, W. Brain Res. (2005) [Pubmed]
  2. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab, F.S., Schlichter, L.C. J. Biol. Chem. (2002) [Pubmed]
  3. Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1. Cayabyab, F.S., Tsui, F.W., Schlichter, L.C. J. Biol. Chem. (2002) [Pubmed]
  4. Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation. Verger, A., Buisine, E., Carrère, S., Wintjens, R., Flourens, A., Coll, J., Stéhelin, D., Duterque-Coquillaud, M. J. Biol. Chem. (2001) [Pubmed]
  5. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya, S., Asakura, K., Muraki, K., Watanabe, M., Imaizumi, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  6. Mutual repression of transcriptional activation between the ETS-related factor ERG and estrogen receptor. Vlaeminck-Guillem, V., Vanacker, J.M., Verger, A., Tomavo, N., Stehelin, D., Laudet, V., Duterque-Coquillaud, M. Oncogene (2003) [Pubmed]
  7. Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart. Rasmussen, H.B., Møller, M., Knaus, H.G., Jensen, B.S., Olesen, S.P., Jørgensen, N.K. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  8. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers, S., Wulfsen, I., Bauer, C.K., Schwarz, J.R. Pflugers Arch. (2001) [Pubmed]
  9. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich, M.J., Machado, E., Rudy, B. J. Neurosci. (2001) [Pubmed]
  10. Metabolism of orally administered ergosterol and 7-dehydrocholesterol in rats and lack of evidence for their vitamin D biological activity. Tsugawa, N., Okano, T., Takeuchi, A., Kayama, M., Kobayashi, T. J. Nutr. Sci. Vitaminol. (1992) [Pubmed]
  11. Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit. Kirchberger, N.M., Wulfsen, I., Schwarz, J.R., Bauer, C.K. J. Physiol. (Lond.) (2006) [Pubmed]
  12. Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells. Gomez-Varela, D., Giraldez, T., de la Pena, P., Dupuy, S.G., Garcia-Manso, D., Barros, F. J. Physiol. (Lond.) (2003) [Pubmed]
  13. Nitric oxide induces [Ca2+]i oscillations in pituitary GH3 cells: involvement of IDR and ERG K+ currents. Secondo, A., Pannaccione, A., Cataldi, M., Sirabella, R., Formisano, L., Di Renzo, G., Annunziato, L. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  14. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. Lecchi, M., Redaelli, E., Rosati, B., Gurrola, G., Florio, T., Crociani, O., Curia, G., Cassulini, R.R., Masi, A., Arcangeli, A., Olivotto, M., Schettini, G., Possani, L.D., Wanke, E. J. Neurosci. (2002) [Pubmed]
 
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