Gene Review:
Xrcc5 - X-ray repair complementing defective...
Mus musculus
Synonyms:
AI314015, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, ...
- Ku86 preserves chromatin integrity in cells adapted to high NaCl. Dmitrieva, N.I., Celeste, A., Nussenzweig, A., Burg, M.B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock. Dynlacht, J.R., Bittner, M.E., Bethel, J.A., Beck, B.D. J. Cell. Physiol. (2003)
- Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80. Tzung, T.Y., Rünger, T.M. Int. J. Radiat. Biol. (1998)
- DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Difilippantonio, M.J., Zhu, J., Chen, H.T., Meffre, E., Nussenzweig, M.C., Max, E.E., Ried, T., Nussenzweig, A. Nature (2000)
- Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Tong, W.M., Cortes, U., Hande, M.P., Ohgaki, H., Cavalli, L.R., Lansdorp, P.M., Haddad, B.R., Wang, Z.Q. Cancer Res. (2002)
- Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Zhu, C., Bogue, M.A., Lim, D.S., Hasty, P., Roth, D.B. Cell (1996)
- Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nussenzweig, A., Chen, C., da Costa Soares, V., Sanchez, M., Sokol, K., Nussenzweig, M.C., Li, G.C. Nature (1996)
- Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. MacLaren, E.J., Bennett, B., Johnson, T.E., Sikela, J.M. Mamm. Genome (2006)
- A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Gao, Y., Chaudhuri, J., Zhu, C., Davidson, L., Weaver, D.T., Alt, F.W. Immunity (1998)
- Deletion of Ku86 causes early onset of senescence in mice. Vogel, H., Lim, D.S., Karsenty, G., Finegold, M., Hasty, P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Goytisolo, F.A., Samper, E., Edmonson, S., Taccioli, G.E., Blasco, M.A. Mol. Cell. Biol. (2001)
- A positive role for the Ku complex in DNA replication following strand break damage in mammals. Park, S.J., Ciccone, S.L., Freie, B., Kurimasa, A., Chen, D.J., Li, G.C., Clapp, D.W., Lee, S.H. J. Biol. Chem. (2004)
- Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Bogue, M.A., Jhappan, C., Roth, D.B. Proc. Natl. Acad. Sci. U.S.A. (1998)
- DNA repair factors and telomere-chromosome integrity in mammalian cells. Hande, M.P. Cytogenet. Genome Res. (2004)
- Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. Ouyang, H., Nussenzweig, A., Kurimasa, A., Soares, V.C., Li, X., Cordon-Cardo, C., Li, W., Cheong, N., Nussenzweig, M., Iliakis, G., Chen, D.J., Li, G.C. J. Exp. Med. (1997)
- Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. Espejel, S., Franco, S., Rodríguez-Perales, S., Bouffler, S.D., Cigudosa, J.C., Blasco, M.A. EMBO J. (2002)
- Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Wu, X., Lieber, M.R. Mol. Cell. Biol. (1996)
- Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Raju, U., Nakata, E., Mason, K.A., Ang, K.K., Milas, L. Cancer Res. (2003)
- Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Arrington, E.D., Caldwell, M.C., Kumaravel, T.S., Lohani, A., Joshi, A., Evans, M.K., Chen, H.T., Nussenzweig, A., Holbrook, N.J., Gorospe, M. Free Radic. Biol. Med. (2000)
- Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo. Belenkov, A.I., Alakhov, V.Y., Kabanov, A.V., Vinogradov, S.V., Panasci, L.C., Monia, B.P., Chow, T.Y. Gene Ther. (2004)
- Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Couëdel, C., Mills, K.D., Barchi, M., Shen, L., Olshen, A., Johnson, R.D., Nussenzweig, A., Essers, J., Kanaar, R., Li, G.C., Alt, F.W., Jasin, M. Genes Dev. (2004)
- Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K., Ferguson, D., Hasty, P., Chun, J., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells. Kanungo, J., Wang, H.Y., Malbon, C.C. Biochem. Biophys. Res. Commun. (2004)
- Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models. Franco, S., Canela, A., Klatt, P., Blasco, M.A. Carcinogenesis (2005)
- Analysis of ku80-mutant mice and cells with deficient levels of p53. Lim, D.S., Vogel, H., Willerford, D.M., Sands, A.T., Platt, K.A., Hasty, P. Mol. Cell. Biol. (2000)
- Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice. Muguruma, M., Nishimura, J., Jin, M., Kashida, Y., Moto, M., Takahashi, M., Yokouchi, Y., Mitsumori, K. Toxicology (2006)
- V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Bogue, M.A., Wang, C., Zhu, C., Roth, D.B. Immunity (1997)
- Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells. Sibani, S., Price, G.B., Zannis-Hadjopoulos, M. J. Cell. Sci. (2005)
- Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues. Koike, M., Matsuda, Y., Mimori, T., Harada, Y.N., Shiomi, N., Shiomi, T. Genomics (1996)
- Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Kim, G.W., Noshita, N., Sugawara, T., Chan, P.H. Stroke (2001)