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Gene Review

LOXL4  -  lysyl oxidase-like 4

Homo sapiens

Synonyms: FLJ21889, LOXC, Lysyl oxidase homolog 4, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C
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Disease relevance of LOXL4

  • CONCLUSION: The data presented in this work might emphasize the involvement of LOXL4 in molecular processes of the genesis or progression of head and neck carcinomas [1].
  • Taken together, these results highlight LOXL4 expression as a distinctive trait and suggest a functional role for LOXL4 in the molecular pathogenesis of invasive head and neck carcinomas [2].

High impact information on LOXL4


Other interactions of LOXL4

  • After amplification and sequencing of the 5'end of the fis clone, subsequent database searches showed an exact match with the coding sequence of the human lysyl oxidase-like gene 4 (LOXL4) [1].


  1. Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas. Holtmeier, C., Görögh, T., Beier, U., Meyer, J., Hoffmann, M., Gottschlich, S., Heidorn, K., Ambrosch, P., Maune, S. Anticancer Res. (2003) [Pubmed]
  2. Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma. Görögh, T., Weise, J.B., Holtmeier, C., Rudolph, P., Hedderich, J., Gottschlich, S., Hoffmann, M., Ambrosch, P., Csiszar, K. J. Pathol. (2007) [Pubmed]
  3. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. Ito, H., Akiyama, H., Iguchi, H., Iyama, K., Miyamoto, M., Ohsawa, K., Nakamura, T. J. Biol. Chem. (2001) [Pubmed]
  4. Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. Mäki, J.M., Tikkanen, H., Kivirikko, K.I. Matrix Biol. (2001) [Pubmed]
  5. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. Asuncion, L., Fogelgren, B., Fong, K.S., Fong, S.F., Kim, Y., Csiszar, K. Matrix Biol. (2001) [Pubmed]
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