High impact information on NAC1

• The transcription activator NAC1, a member of the NAM/CUC family of transcription factors, functions downstream of TIR1 to transduce the auxin signal for lateral root development [1].
• Here we show that SINAT5, an Arabidopsis homologue of the RING-finger Drosophila protein SINA, has ubiquitin protein ligase activity and can ubiquitinate NAC1 [1].
• SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals [1].
• These lateral root phenotypes correlate with the expression of NAC1 observed in vivo [1].
• We show here that NAC1, a new member of the NAC family, is induced by auxin and mediates auxin signaling to promote lateral root development [2].

Biological context of NAC1

• Cleavage was blocked by NAC1 mutations that disrupt base pairing with miR164 [3].

Associations of NAC1 with chemical compounds

• NAC1 is a transcription activator consisting of an N-terminal conserved NAC-domain that binds to DNA and a C-terminal activation domain [2].

Other interactions of NAC1

• By contrast, inducible expression of miR164 in wild-type plants led to decreased NAC1 mRNA levels and reduced lateral root emergence [3].

References