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Gene Review

CLV2  -  leucine-rich repeat receptor-like protein...

Arabidopsis thaliana

Synonyms: AtRLP10, Receptor Like Protein 10, T8F5.16, T8F5_16, clavata 2
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High impact information on CLV2

  • Crossing of the CLE19 overexpression line with clv mutants confirms the involvement of CLV2 [1].
  • Other components of the CLV1 signaling pathway include the secreted putative ligand CLV3 and the receptor-like protein CLV2 [2].
  • We used genetic and immunological assays to show that CLV3 localizes to the apoplast and that export to the extracellular space is required for its function in activating the CLV1/CLV2 receptor complex [3].
  • We isolated the CLV2 gene and found that it encodes a receptor-like protein (RLP), with a presumed extracellular domain composed of leucine-rich repeats similar to those found in plant and animal receptors, but with a very short predicted cytoplasmic tail [4].
  • In addition, the chromosomal region in which CLV2 is located contains an extremely high rate of polymorphism, with 50 nucleotide and 15 amino acid differences between Landsberg erecta and Columbia ecotypes within the CLV2 coding sequence [4].

Biological context of CLV2

  • These alterations include flower-to-shoot transformations, as well as a nearly complete suppression of the flower phenotypes, indicating that the requirement for CLV2 changes in response to different physiological conditions [5].
  • Most alleles at CLV2 are found in one of three haplotype groups of moderate (>15%) frequency [6].
  • The levels and patterns of nucleotide variation were assessed for CLV2 and 10 flanking genes that together span a 40-kb region of chromosome I. A total of 296 out of 7959 sequenced nucleotide sites were polymorphic [6].
  • CLV2 has the highest levels of nucleotide variation in this region, a significant excess of intermediate frequency polymorphisms, and significant levels of intragenic linkage disequilibrium [6].

Anatomical context of CLV2


Other interactions of CLV2

  • We present genetic analysis that CLV2 may function in the same pathway as CLV1 and CLV3 in the regulation of meristem development, but function separately in the regulation of organ development [5].

Analytical, diagnostic and therapeutic context of CLV2

  • Sequence analysis suggests that the charged residue in the predicted transmembrane domain of CLV2 may be a common feature of plant RLPs and RLKs [4].


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