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Gene Review

KNAT2  -  homeobox protein knotted-1-like 2

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA KN 1, ATK1, F24J13.8, F24J13_8, KNOTTED-like from Arabidopsis thaliana 2
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High impact information on KNAT2

  • To investigate their role, we identified null alleles of KNAT6 and KNAT2 [1].
  • To investigate its role, we used a DEXAMETHASONE (DEX)-inducible system to generate transgenic plants that overexpressed a fusion of KNAT2 with the hormone binding domain of the glucocorticoid receptor [2].
  • Intron positions are also fairly well conserved among KNAT1, KNAT2, and kn1 [3].
  • Misexpression of the knox genes, KNAT1 or KNAT2, in Arabidopsis produces a variety of phenotypes, including lobed leaves and ectopic stipules and meristems in the sinus, the region between lobes [4].
  • The KNAT2 expression pattern defines an enlarged meristematic zone in pas mutants that can be mimicked in wild type by cytokinin treatment [5].

Biological context of KNAT2


Associations of KNAT2 with chemical compounds


Other interactions of KNAT2

  • Analysis by the reverse transcription-polymerase chain reaction showed that transcripts of the KNAT1, KNAT2 and KNAT6 (a recently identified member of the class 1 knox family) genes accumulated in the leaves of both as2 and as1 plants but not of wild type [9].
  • Using a transgenic line that overexpresses a fusion of the KNAT2 (KNOTTED-like Arabidopsis) homeodomain protein and the hormone-binding domain of the glucocorticoid receptor (GR), we have investigated the possible relations between KNAT2 and various hormones [6].


  1. KNAT6: an Arabidopsis homeobox gene involved in meristem activity and organ separation. Belles-Boix, E., Hamant, O., Witiak, S.M., Morin, H., Traas, J., Pautot, V. Plant Cell (2006) [Pubmed]
  2. KNAT2: evidence for a link between knotted-like genes and carpel development. Pautot, V., Dockx, J., Hamant, O., Kronenberger, J., Grandjean, O., Jublot, D., Traas, J. Plant Cell (2001) [Pubmed]
  3. A knotted1-like homeobox gene in Arabidopsis is expressed in the vegetative meristem and dramatically alters leaf morphology when overexpressed in transgenic plants. Lincoln, C., Long, J., Yamaguchi, J., Serikawa, K., Hake, S. Plant Cell (1994) [Pubmed]
  4. Mechanisms that control knox gene expression in the Arabidopsis shoot. Ori, N., Eshed, Y., Chuck, G., Bowman, J.L., Hake, S. Development (2000) [Pubmed]
  5. Hormonal control of cell proliferation requires PASTICCINO genes. Harrar, Y., Bellec, Y., Bellini, C., Faure, J.D. Plant Physiol. (2003) [Pubmed]
  6. The KNAT2 homeodomain protein interacts with ethylene and cytokinin signaling. Hamant, O., Nogué, F., Belles-Boix, E., Jublot, D., Grandjean, O., Traas, J., Pautot, V. Plant Physiol. (2002) [Pubmed]
  7. The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants. Dockx, J., Quaedvlieg, N., Keultjes, G., Kock, P., Weisbeek, P., Smeekens, S. Plant Mol. Biol. (1995) [Pubmed]
  8. Ion channels in guard cells of Arabidopsis thaliana (L.) Heynh.. Roelfsema, M.R., Prins, H.B. Planta (1997) [Pubmed]
  9. The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates formation of a symmetric lamina, establishment of venation and repression of meristem-related homeobox genes in leaves. Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., Machida, Y. Development (2001) [Pubmed]
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