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Gene Review

KNAT1  -  homeobox protein knotted-1-like 1

Arabidopsis thaliana

Synonyms: BP, BP1, BREVIPEDICELLUS, BREVIPEDICELLUS 1, F9M13.2, ...
 
 
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Disease relevance of KNAT1

 

High impact information on KNAT1

 

Biological context of KNAT1

  • In the shoot apex, KNAT1 transcript is localized primarily to the shoot apical meristem; down-regulation of expression occurs as leaf primordia are initiated [1].
  • The expression pattern of KNAT1 in the shoot meristem combined with the results of transgenic overexpression experiments supports the hypothesis that class 1 kn1-like genes play a role in morphogenesis [1].
  • Misexpression of the knox genes, KNAT1 or KNAT2, in Arabidopsis produces a variety of phenotypes, including lobed leaves and ectopic stipules and meristems in the sinus, the region between lobes [6].
  • The steady state transcript levels of the histidine kinase CKI1 gene and the KNAT1 and STM homeobox genes were increased in tsd mutants, while mRNA levels of cell cycle genes were not altered [7].
  • In addition, bp plants displayed defects in cell differentiation and radial growth of the style [8].
 

Anatomical context of KNAT1

  • We have used a second-site suppressor screen to isolate mutations in KNAT1 and we show that KNAT1 is partially redundant with STM in regulating stem cell function [9].
 

Associations of KNAT1 with chemical compounds

  • Intron positions are also fairly well conserved among KNAT1, KNAT2, and kn1 [1].
  • DEX-induced plants were similar to plants overexpressing the closely related KNAT1 gene, indicating overlapping functions, although we observed differences as well [10].
  • Increased steady state mRNA levels of the STM and KNAT1 homeobox genes in cytokinin overproducing Arabidopsis thaliana indicate a role for cytokinins in the shoot apical meristem [11].
  • ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis [12].
  • Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1 [13].
 

Regulatory relationships of KNAT1

  • Here, we show that auxin and AS1 pathways converge to repress expression of the KNOX gene BREVIPEDICELLUS (BP) and thus promote leaf fate [12].
 

Other interactions of KNAT1

  • The physical association of the PNY and BP proteins suggests that they participate in a complex that regulates early patterning events in the inflorescence meristem [4].
  • Analysis by the reverse transcription-polymerase chain reaction showed that transcripts of the KNAT1, KNAT2 and KNAT6 (a recently identified member of the class 1 knox family) genes accumulated in the leaves of both as2 and as1 plants but not of wild type [14].
  • Interaction is mediated by BEL1 sequences N terminal to the homeodomain and KNAT sequences including the MEINOX domain [15].
  • Domain exchanges between KNAT3 and KNAT1 suggest specificity of the kn1-like homeodomains requires sequences outside of the third helix and N-terminal arm of the homeodomain [16].
  • KNAT1 and ERECTA regulate inflorescence architecture in Arabidopsis [5].
 

Analytical, diagnostic and therapeutic context of KNAT1

  • Based on in situ hybridization analysis, the expression pattern of KNAT1 during vegetative development is similar to that of class 1 maize genes [1].

References

  1. A knotted1-like homeobox gene in Arabidopsis is expressed in the vegetative meristem and dramatically alters leaf morphology when overexpressed in transgenic plants. Lincoln, C., Long, J., Yamaguchi, J., Serikawa, K., Hake, S. Plant Cell (1994) [Pubmed]
  2. The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways. Mele, G., Ori, N., Sato, Y., Hake, S. Genes Dev. (2003) [Pubmed]
  3. The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development. Li, H., Xu, L., Wang, H., Yuan, Z., Cao, X., Yang, Z., Zhang, D., Xu, Y., Huang, H. Plant Cell (2005) [Pubmed]
  4. The interaction of two homeobox genes, BREVIPEDICELLUS and PENNYWISE, regulates internode patterning in the Arabidopsis inflorescence. Smith, H.M., Hake, S. Plant Cell (2003) [Pubmed]
  5. KNAT1 and ERECTA regulate inflorescence architecture in Arabidopsis. Douglas, S.J., Chuck, G., Dengler, R.E., Pelecanda, L., Riggs, C.D. Plant Cell (2002) [Pubmed]
  6. Mechanisms that control knox gene expression in the Arabidopsis shoot. Ori, N., Eshed, Y., Chuck, G., Bowman, J.L., Hake, S. Development (2000) [Pubmed]
  7. Tumorous shoot development (TSD) genes are required for co-ordinated plant shoot development. Frank, M., Guivarc'h, A., Krupková, E., Lorenz-Meyer, I., Chriqui, D., Schmülling, T. Plant J. (2002) [Pubmed]
  8. The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis. Venglat, S.P., Dumonceaux, T., Rozwadowski, K., Parnell, L., Babic, V., Keller, W., Martienssen, R., Selvaraj, G., Datla, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis. Byrne, M.E., Simorowski, J., Martienssen, R.A. Development (2002) [Pubmed]
  10. KNAT2: evidence for a link between knotted-like genes and carpel development. Pautot, V., Dockx, J., Hamant, O., Kronenberger, J., Grandjean, O., Jublot, D., Traas, J. Plant Cell (2001) [Pubmed]
  11. Increased steady state mRNA levels of the STM and KNAT1 homeobox genes in cytokinin overproducing Arabidopsis thaliana indicate a role for cytokinins in the shoot apical meristem. Rupp, H.M., Frank, M., Werner, T., Strnad, M., Schmülling, T. Plant J. (1999) [Pubmed]
  12. ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis. Hay, A., Barkoulas, M., Tsiantis, M. Development (2006) [Pubmed]
  13. Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. Okada, K., Hase, T. J. Biol. Chem. (2005) [Pubmed]
  14. The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates formation of a symmetric lamina, establishment of venation and repression of meristem-related homeobox genes in leaves. Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., Machida, Y. Development (2001) [Pubmed]
  15. The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals. Bellaoui, M., Pidkowich, M.S., Samach, A., Kushalappa, K., Kohalmi, S.E., Modrusan, Z., Crosby, W.L., Haughn, G.W. Plant Cell (2001) [Pubmed]
  16. Domain exchanges between KNAT3 and KNAT1 suggest specificity of the kn1-like homeodomains requires sequences outside of the third helix and N-terminal arm of the homeodomain. Serikawa, K.A., Zambryski, P.C. Plant J. (1997) [Pubmed]
 
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