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Gene Review

DYRK2  -  dual-specificity tyrosine-(Y)...

Homo sapiens

Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2
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Disease relevance of DYRK2


High impact information on DYRK2


Other interactions of DYRK2

  • By fluorescence microscopy and subcellular fractionation, a green fluorescent protein (GFP) fusion protein of DYRK1A was found to accumulate in the nucleus of transfected COS-7 and HEK293 cells, whereas GFP-DYRK2 was predominantly detected in the cytoplasm [5].
  • Unlike complex DYRKs 1A, 1B, and 4A, DYRK3 and DYRK2 possess simple 4-exon structures [6].


  1. Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. Miller, C.T., Aggarwal, S., Lin, T.K., Dagenais, S.L., Contreras, J.I., Orringer, M.B., Glover, T.W., Beer, D.G., Lin, L. Cancer Res. (2003) [Pubmed]
  2. Mdm2: p53's Lifesaver? Shmueli, A., Oren, M. Mol. Cell (2007) [Pubmed]
  3. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. Skurat, A.V., Dietrich, A.D. J. Biol. Chem. (2004) [Pubmed]
  4. Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Gorringe, K.L., Boussioutas, A., Bowtell, D.D. Genes Chromosomes Cancer (2005) [Pubmed]
  5. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker, W., Weber, Y., Wetzel, K., Eirmbter, K., Tejedor, F.J., Joost, H.G. J. Biol. Chem. (1998) [Pubmed]
  6. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. Zhang, D., Li, K., Erickson-Miller, C.L., Weiss, M., Wojchowski, D.M. Genomics (2005) [Pubmed]
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