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Gene Review

DYRK1B  -  dual-specificity tyrosine-(Y)...

Homo sapiens

Synonyms: AOMS3, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, MIRK, Minibrain-related kinase, Mirk protein kinase
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Disease relevance of DYRK1B


High impact information on DYRK1B

  • Mirk is a stress-activated kinase that mediates expression of contractile proteins in differentiating myoblasts, but Mirk is not essential for muscle formation in the embryo [3].
  • Mirk was detected in each rhabdomyosarcoma cell line examined [3].
  • The function of the serine/threonine kinase Mirk was investigated in this cancer [3].
  • The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma [4].
  • It is likely that Mirk also facilitates survival of satellite cell-derived rhabdomyoblasts in regenerating skeletal muscle and aids their differentiation [3].

Chemical compound and disease context of DYRK1B


Biological context of DYRK1B


Anatomical context of DYRK1B


Associations of DYRK1B with chemical compounds


Regulatory relationships of DYRK1B

  • In each of three colon carcinoma cell lines, mirk levels were increased 20-fold when erk activation was blocked by the MEK inhibitor PD98059 in serum-free medium [2].
  • RanBPM inhibited the kinase activity of Mirk/Dyrk1B and Dyrk1A [5].

Other interactions of DYRK1B


Analytical, diagnostic and therapeutic context of DYRK1B


  1. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. Lim, S., Jin, K., Friedman, E. J. Biol. Chem. (2002) [Pubmed]
  2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. Lee, K., Deng, X., Friedman, E. Cancer Res. (2000) [Pubmed]
  3. Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas. Mercer, S.E., Ewton, D.Z., Shah, S., Naqvi, A., Friedman, E. Cancer Res. (2006) [Pubmed]
  4. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. Deng, X., Ewton, D.Z., Li, S., Naqvi, A., Mercer, S.E., Landas, S., Friedman, E. Cancer Res. (2006) [Pubmed]
  5. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M. Zou, Y., Lim, S., Lee, K., Deng, X., Friedman, E. J. Biol. Chem. (2003) [Pubmed]
  6. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. Leder, S., Weber, Y., Altafaj, X., Estivill, X., Joost, H.G., Becker, W. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  7. The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site. de Graaf, K., Czajkowska, H., Rottmann, S., Packman, L.C., Lilischkis, R., Lüscher, B., Becker, W. BMC Biochem. (2006) [Pubmed]
  8. Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties. Leder, S., Czajkowska, H., Maenz, B., De Graaf, K., Barthel, A., Joost, H.G., Becker, W. Biochem. J. (2003) [Pubmed]
  9. Involvement of GSK-3beta and DYRK1B in Differentiation-inducing Factor-3-induced Phosphorylation of Cyclin D1 in HeLa Cells. Takahashi-Yanaga, F., Mori, J., Matsuzaki, E., Watanabe, Y., Hirata, M., Miwa, Y., Morimoto, S., Sasaguri, T. J. Biol. Chem. (2006) [Pubmed]
  10. The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. Jin, K., Lim, S., Mercer, S.E., Friedman, E. J. Biol. Chem. (2005) [Pubmed]
  11. Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. Ewton, D.Z., Lee, K., Deng, X., Lim, S., Friedman, E. Int. J. Cancer (2003) [Pubmed]
  12. The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. Lim, S., Zou, Y., Friedman, E. J. Biol. Chem. (2002) [Pubmed]
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