High impact information on Otof

• In agreement with previous studies, otoferlin expression was found in the brain and in inner and vestibular hair cells [1].
• Several studies have demonstrated expression of otoferlin in the inner ear and brain, and suggested a role of otoferlin in Ca(2+)-triggered exocytosis [1].
• Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat [1].
• Otoferlin mRNA and protein was, however, also detected in mature outer hair cells of low-frequency processing cochlear turns and in auditory nerve fibres [1].

Anatomical context of Otof

• In outer, inner and vestibular hair cells, otoferlin was subcellularly localized at a considerable distance from the presumed active release sites [1].

Analytical, diagnostic and therapeutic context of Otof

• Here, we analysed the expression of otoferlin protein and mRNA using immunohistochemistry, in situ hybridization and RT-PCR in neonatal and mature Wistar rat tissue [1].

References