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Otof  -  otoferlin

Rattus norvegicus

Synonyms: Fer-1-like protein 2, Fer1l2, Otoferlin
 
 
 
 
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High impact information on Otof

  • In agreement with previous studies, otoferlin expression was found in the brain and in inner and vestibular hair cells [1].
  • Several studies have demonstrated expression of otoferlin in the inner ear and brain, and suggested a role of otoferlin in Ca(2+)-triggered exocytosis [1].
  • Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat [1].
  • Otoferlin mRNA and protein was, however, also detected in mature outer hair cells of low-frequency processing cochlear turns and in auditory nerve fibres [1].
 

Anatomical context of Otof

  • In outer, inner and vestibular hair cells, otoferlin was subcellularly localized at a considerable distance from the presumed active release sites [1].
 

Analytical, diagnostic and therapeutic context of Otof

References

  1. Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat. Schug, N., Braig, C., Zimmermann, U., Engel, J., Winter, H., Ruth, P., Blin, N., Pfister, M., Kalbacher, H., Knipper, M. Eur. J. Neurosci. (2006) [Pubmed]
 
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