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MeSH Review

Hair Cells, Vestibular

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Disease relevance of Hair Cells, Vestibular


High impact information on Hair Cells, Vestibular


Chemical compound and disease context of Hair Cells, Vestibular


Biological context of Hair Cells, Vestibular


Anatomical context of Hair Cells, Vestibular


Associations of Hair Cells, Vestibular with chemical compounds

  • Gentamicin administration often results in cochlear and/or vestibular hair cell loss and hearing and balance impairment [17].
  • In the second experiment, 1-wk-old chicks were treated with streptomycin, which destroys most vestibular hair cells and reduces hVOR gain to zero [18].
  • Afferent nerve calyces which surround type I vestibular hair cells (VHCI) have recently been shown to contain synaptic-like vesicles and to be immunoreactive to glutamate antibodies [19].
  • The application of ACh can mimic efferent stimulation in producing both an inhibition and a facilitation of afferent discharge which are thought to be mediated by at least two distinct ACh receptors present on vestibular hair cells, i.e., alpha9-containing nicotinic receptors (alpha9nAChR) and muscarinic receptors (mAChR), respectively [20].
  • The present findings suggest that glutamate released at the afferent synapse of vestibular hair cells may be taken up by adjacent supporting cells and converted into glutamine [21].

Gene context of Hair Cells, Vestibular


Analytical, diagnostic and therapeutic context of Hair Cells, Vestibular


  1. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Xiang, M., Gan, L., Li, D., Chen, Z.Y., Zhou, L., O'Malley, B.W., Klein, W., Nathans, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Impaired tunnel-maze behavior in rats with sensory lesions: vestibular and auditory systems. Schaeppi, U., Krinke, G., FitzGerald, R.E., Classen, W. Neurotoxicology (1991) [Pubmed]
  3. Math1: an essential gene for the generation of inner ear hair cells. Bermingham, N.A., Hassan, B.A., Price, S.D., Vollrath, M.A., Ben-Arie, N., Eatock, R.A., Bellen, H.J., Lysakowski, A., Zoghbi, H.Y. Science (1999) [Pubmed]
  4. Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. Kharkovets, T., Dedek, K., Maier, H., Schweizer, M., Khimich, D., Nouvian, R., Vardanyan, V., Leuwer, R., Moser, T., Jentsch, T.J. EMBO J. (2006) [Pubmed]
  5. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function. Kopke, R.D., Jackson, R.L., Li, G., Rasmussen, M.D., Hoffer, M.E., Frenz, D.A., Costello, M., Schultheiss, P., Van De Water, T.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Interactions in the network of Usher syndrome type 1 proteins. Adato, A., Michel, V., Kikkawa, Y., Reiners, J., Alagramam, K.N., Weil, D., Yonekawa, H., Wolfrum, U., El-Amraoui, A., Petit, C. Hum. Mol. Genet. (2005) [Pubmed]
  7. Calpain immunoreactivity and morphological damage in chinchilla inner ears after carboplatin. Ding, L., McFadden, S.L., Salvi, R.J. J. Assoc. Res. Otolaryngol. (2002) [Pubmed]
  8. Quantitative changes in mRNA expression of glutamate receptors in the rat peripheral and central vestibular systems following hypergravity. Uno, Y., Horii, A., Uno, A., Fuse, Y., Fukushima, M., Doi, K., Kubo, T. J. Neurochem. (2002) [Pubmed]
  9. Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Zhang, M., Liu, W., Ding, D., Salvi, R. Neuroscience (2003) [Pubmed]
  10. Cycloheximide blocks the toxic effect of streptomycin in guinea pig vestibular hair cells. Nakagawa, T., Yamane, H., Takayama, M., Sunami, K., Nakai, Y. Acta oto-laryngologica. Supplementum. (1998) [Pubmed]
  11. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. Senften, M., Schwander, M., Kazmierczak, P., Lillo, C., Shin, J.B., Hasson, T., Géléoc, G.S., Gillespie, P.G., Williams, D., Holt, J.R., Müller, U. J. Neurosci. (2006) [Pubmed]
  12. Receptor-stimulated phospholipase A(2) liberates arachidonic acid and regulates neuronal excitability through protein kinase C. Muzzio, I.A., Gandhi, C.C., Manyam, U., Pesnell, A., Matzel, L.D. J. Neurophysiol. (2001) [Pubmed]
  13. Calcitonin-gene-related-peptide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures. Silverman, J.D., Kruger, L. J. Comp. Neurol. (1989) [Pubmed]
  14. Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro. Matsui, J.I., Gale, J.E., Warchol, M.E. J. Neurobiol. (2004) [Pubmed]
  15. Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular periphery. Ishiyama, G., Lopez, I., Williamson, R., Acuna, D., Ishiyama, A. Brain Res. (2002) [Pubmed]
  16. The protective effect of brain-derived neurotrophic factor after gentamicin ototoxicity. Lopez, I., Honrubia, V., Lee, S.C., Chung, W.H., Li, G., Beykirch, K., Micevych, P. The American journal of otology. (1999) [Pubmed]
  17. Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity. Suzuki, M., Yagi, M., Brown, J.N., Miller, A.L., Miller, J.M., Raphael, Y. Gene Ther. (2000) [Pubmed]
  18. Visual influences on the development and recovery of the vestibuloocular reflex in the chicken. Goode, C.T., Maney, D.L., Rubel, E.W., Fuchs, A.F. J. Neurophysiol. (2001) [Pubmed]
  19. Glutamate receptors on type I vestibular hair cells of guinea-pig. Devau, G., Lehouelleur, J., Sans, A. Eur. J. Neurosci. (1993) [Pubmed]
  20. A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells. Holt, J.C., Lioudyno, M., Guth, P.S. J. Neurophysiol. (2003) [Pubmed]
  21. Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ. Takumi, Y., Matsubara, A., Danbolt, N.C., Laake, J.H., Storm-Mathisen, J., Usami, S., Shinkawa, H., Ottersen, O.P. Neuroscience (1997) [Pubmed]
  22. A role for BDNF in early postnatal rat vestibular epithelia maturation: implication of supporting cells. Montcouquiol, M., Valat, J., Travo, C., Sans, A. Eur. J. Neurosci. (1998) [Pubmed]
  23. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. Wang, Y., Guo, N., Nathans, J. J. Neurosci. (2006) [Pubmed]
  24. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker. Zheng, J.L., Gao, W.Q. J. Neurosci. (1997) [Pubmed]
  25. E-cadherin and the differentiation of mammalian vestibular hair cells. Hackett, L., Davies, D., Helyer, R., Kennedy, H., Kros, C., Lawlor, P., Rivolta, M.N., Holley, M. Exp. Cell Res. (2002) [Pubmed]
  26. Intramuscular streptomycin effect on dark cells of utricle in guinea pigs. Ge, X., Shea, J.J. The American journal of otology. (1993) [Pubmed]
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