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Gene Review

GPT2  -  glutamic pyruvate transaminase (alanine...

Homo sapiens

Synonyms: AAT2, ALT2, Alanine aminotransferase 2, GPT 2, Glutamate pyruvate transaminase 2, ...
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Disease relevance of GPT2

  • With respect to the patient who was G+C- and showed high values of GPT 2 and 3 years post transplant, we suspect that his liver dysfunction might have been caused by some unknown virus or etiology [1].

High impact information on GPT2

  • Murine ALT genes localize to separate chromosomes, with mALT1 gene (gpt1) on chromosome 15 and mALT2 gene (gpt2) on chromosome 8 [2].
  • The human gene GPT2 encodes a 3.9-kb mRNA, consists of 12 exons, spanning approximately 50 kb of the genome, and maps to chromosome 16q12 [3].
  • The more abundant expression of GPT2 than GPT, especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis [3].
  • Two new variant phenotypes were detected, neither of which could be distinguished from GPT2-1 and GPT2 by conventional starch gel electrophoresis [4].
  • The observed gene frequencies for the polymorphic systems are: ACPA = 0.293, ACPB = 0.667 and ACPC = 0.040; GLO1 = 0.372; GPT2 = 0.462; UMPK2 = 0.029; PGM21 = 0.279; PGDC = 0.037; PGP1 = 0.953, PGP2 = 0.038 and PGP3 = 0.009 [5].

Associations of GPT2 with chemical compounds

  • The two polymorphic GPT isozymes are the results of a nucleotide substitution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restriction site [6].


  1. Long-term liver function of recipients with hepatitis G virus infection after bone marrow transplantation. Maruta, A., Tanabe, J., Hashimoto, C., Kato, K., Kanamori, H., Fukawa, H., Miyashita, H., Fujisawa, S., Fujita, H., Matsuzaki, M., Motomura, S., Kodama, F., Ookawa, S., Mohri, H., Ishigatsubo, Y. Bone Marrow Transplant. (1999) [Pubmed]
  2. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. Jadhao, S.B., Yang, R.Z., Lin, Q., Hu, H., Anania, F.A., Shuldiner, A.R., Gong, D.W., Jadaho, S.B. Hepatology (2004) [Pubmed]
  3. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Yang, R.Z., Blaileanu, G., Hansen, B.C., Shuldiner, A.R., Gong, D.W. Genomics (2002) [Pubmed]
  4. Genetic polymorphism of red cell glutamate-pyruvate transaminase in Japanese. Toyomasu, T., Mukaida, M. Hum. Hered. (1987) [Pubmed]
  5. A study of ten red cell enzymatic markers in the Naples' population. Report of a new GPT variant phenotype. Ranzani, G.N., Antonini, G., Beretta, M., Santachiara Benerecetti, A.S. Z. Rechtsmed. (1982) [Pubmed]
  6. Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. Sohocki, M.M., Sullivan, L.S., Harrison, W.R., Sodergren, E.J., Elder, F.F., Weinstock, G., Tanase, S., Daiger, S.P. Genomics (1997) [Pubmed]
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