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Gene Review:

RELT - RELT tumor necrosis factor receptor

Homo sapiens

Synonyms: FLJ14993, Receptor expressed in lymphoid tissues, TNFRSF19L, TRLT, Tumor necrosis factor receptor superfamily member 19L

Sica, G.L. et al., Cusick, J.K. et al., Polek, T.C. et al.

Cusick, Xu, Bin, Han, Shu,

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Disease relevance of TNFRSF19L

The messenger RNA of RELT is especially abundant in hematologic tissues such as spleen, lymph node, and peripheral blood leukocytes as well as in leukemias and lymphomas [1].

High impact information on TNFRSF19L

This study reports the cloning of a new member of the TNFR superfamily, RELT (Receptor Expressed in Lymphoid Tissues) [1].
Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT is capable of costimulating T-cell proliferation in the presence of CD3 signaling [1].
Using a yeast two-hybrid system, we identified a Ste20-related proline-alanine-rich kinase (SPAK) that binds RELT [2].
We propose that RELL1 and RELL2 be considered RELT family members based on their similar amino acid sequences and on their ability to physically interact with one another [3].
RELT, RELL1, and RELL2 co-localized with one another at the plasma membrane [3].

Other interactions of TNFRSF19L

In addition, a kinase-dead SPAK acted as an inhibitor of RELT signaling [2].

Analytical, diagnostic and therapeutic context of TNFRSF19L

OSR1 was identified through a yeast two-hybrid screen utilizing the intracellular portion of RELL1 as bait, and OSR1 was shown to interact with the three RELT family members by in vitro co-immunoprecipitation experiments [3].

References

RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Sica, G.L., Zhu, G., Tamada, K., Liu, D., Ni, J., Chen, L. Blood (2001) [Pubmed]
The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Polek, T.C., Talpaz, M., Spivak-Kroizman, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Cusick, J.K., Xu, L.G., Bin, L.H., Han, K.J., Shu, H.B. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

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RELT	Bos taurus
RELT	Canis lupus familiaris
relt	Danio rerio
RELT	Gallus gallus
Relt	Mus musculus
RELT	Pan troglodytes
Relt	Rattus norvegicus

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