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Gene Review

HIS2  -  histidinol-phosphatase

Saccharomyces cerevisiae S288c

Synonyms: Histidinol-phosphatase, HolPase, YFR025C
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Disease relevance of HIS2


High impact information on HIS2

  • The frequency of DSBs at HIS2 increases when the gene conversion frequency is increased by alterations in the DNA around HIS2, and vice versa [2].
  • This paper shows that DSBs occur in meiosis at a site in the coding region and at a site downstream of the HIS2 gene and that the DSBs are dependent upon genes required for recombination [2].
  • We have previously demonstrated that the HIS2 gene is a recombination hot spot, exhibiting a high frequency of gene conversion and associated crossing over [2].
  • Cys2/His2-type zinc finger proteins, which contain the EAR transcriptional repressor domain, are thought to play a key role in regulating the defense response of plants to biotic and abiotic stress conditions [3].
  • Previous studies of hotspots, including HIS2, suggest that global chromosome structure plays a significant role in recombination activity, raising the question of how much DNA is sufficient for hotspot activity [4].

Biological context of HIS2

  • Data presented here suggest that at least some of the sequences necessary for high levels of conversion at HIS2 are located over 700 bp downstream of the end of the coding region, extend over (at least) several hundred base pairs, and may be quite complex, perhaps involving chromatin structure [5].
  • All disruptants exhibited the expected auxotrophic phenotypes, with only the his2 knockouts displaying a bradytroph phenotype [6].

Anatomical context of HIS2

  • A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain [7].

Associations of HIS2 with chemical compounds

  • HolPase activity could not be detected in crude extracts of the ytvP mutant, while purified glutathione S-transferase-YtvP fusion protein exhibited strong HolPase activity [8].

Other interactions of HIS2

  • Finally, mutations in either HOP1 or RED1 reduce the number of double-strand breaks observed at the HIS2 meiotic recombination hotspot [9].


  1. Isolation and characterization of cDNAs encoding imidazoleglycerolphosphate dehydratase from Arabidopsis thaliana. Tada, S., Volrath, S., Guyer, D., Scheidegger, A., Ryals, J., Ohta, D., Ward, E. Plant Physiol. (1994) [Pubmed]
  2. Double strand breaks at the HIS2 recombination hot spot in Saccharomyces cerevisiae. Bullard, S.A., Kim, S., Galbraith, A.M., Malone, R.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. The EAR-motif of the Cys2/His2-type Zinc Finger Protein Zat7 Plays a Key Role in the Defense Response of Arabidopsis to Salinity Stress. Ciftci-Yilmaz, S., Morsy, M.R., Song, L., Coutu, A., Krizek, B.A., Lewis, M.W., Warren, D., Cushman, J., Connolly, E.L., Mittler, R. J. Biol. Chem. (2007) [Pubmed]
  4. Properties of natural double-strand-break sites at a recombination hotspot in Saccharomyces cerevisiae. Haring, S.J., Halley, G.R., Jones, A.J., Malone, R.E. Genetics (2003) [Pubmed]
  5. Analysis of a recombination hotspot for gene conversion occurring at the HIS2 gene of Saccharomyces cerevisiae. Malone, R.E., Kim, S., Bullard, S.A., Lundquist, S., Hutchings-Crow, L., Cramton, S., Lutfiyya, L., Lee, J. Genetics (1994) [Pubmed]
  6. Cloning and disruption of the Pichia pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5, HIS6 genes and their use as auxotrophic markers. Nett, J.H., Hodel, N., Rausch, S., Wildt, S. Yeast (2005) [Pubmed]
  7. A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain. Pott, U., Thiesen, H.J., Colello, R.J., Schwab, M.E. J. Neurochem. (1995) [Pubmed]
  8. Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis. le Coq, D., Fillinger, S., Aymerich, S. J. Bacteriol. (1999) [Pubmed]
  9. Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae. Mao-Draayer, Y., Galbraith, A.M., Pittman, D.L., Cool, M., Malone, R.E. Genetics (1996) [Pubmed]
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