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Gene Review

RED1  -  Red1p

Saccharomyces cerevisiae S288c

Synonyms: L8479.6, Protein RED1, Reductional division protein 1, YLR263W
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High impact information on RED1


Biological context of RED1

  • We report here the effects of mutations in two other (meiosis-specific) genes, RED1 and MEK1/MRE4, that encode a chromosome structure component and a protein kinase, respectively [4].
  • Mutants in the meiosis-specific RED1 gene of S. cerevisiae fail to make any synaptonemal complex (SC) or any obvious precursors to the SC [5].
  • Unlike the S. cerevisiae RED1 gene, the K. lactis RED1 contains an intron; the transcript of the K. lactis gene is efficiently spliced during meiosis in S. cerevisiae [6].
  • These two different results can be explained because the data presented here indicate that a rad50S mutation does not diminish meiotic intrachromosomal recombination, similar to the mutant phenotypes conferred by red1 or hop1 [7].
  • On the other hand, suppression by overexpression of RED1 from a 2 mu plasmid was found only for allele hop1-628ts [8].

Physical interactions of RED1

  • Our data strongly support the idea that RED1 protein is also a component of the synaptonemal complex and further suggest that the RED1 and HOP1 gene products may interact [9].

Other interactions of RED1

  • Coordinate action of mitotic recA homologs as one functional unit, two functions of RED1, and an interhomolog interaction function of DMC1 are also revealed [10].
  • HOP1 and RED1 have been classified as such early genes [7].
  • Double labeling of wild-type meiotic chromosomes with anti-Zip1 and anti-Red1 antibodies demonstrates that Red1 localizes to chromosomes both before and during pachytene [5].
  • We demonstrate that a mutation in a gene (REC104) required for initiation of exchange is completely epistatic to a mutation in RED1 [7].
  • Analysis of the spo11 mutant demonstrates that Red1 localization does not depend upon meiotic recombination [5].

Analytical, diagnostic and therapeutic context of RED1

  • Northern blot hybridization analysis indicates that the RED1 gene produces two transcripts of 2.75 and 3.2 kilobases [11].


  1. Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Blat, Y., Protacio, R.U., Hunter, N., Kleckner, N. Cell (2002) [Pubmed]
  2. Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Bailis, J.M., Roeder, G.S. Cell (2000) [Pubmed]
  3. Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein. Bailis, J.M., Roeder, G.S. Genes Dev. (1998) [Pubmed]
  4. Meiotic cells monitor the status of the interhomolog recombination complex. Xu, L., Weiner, B.M., Kleckner, N. Genes Dev. (1997) [Pubmed]
  5. The yeast Red1 protein localizes to the cores of meiotic chromosomes. Smith, A.V., Roeder, G.S. J. Cell Biol. (1997) [Pubmed]
  6. Cloning and characterization of the Kluyveromyces lactis homologs of the Saccharomyces cerevisiae RED1 and HOP1 genes. Smith, A.V., Roeder, G.S. Chromosoma (2000) [Pubmed]
  7. Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae. Mao-Draayer, Y., Galbraith, A.M., Pittman, D.L., Cool, M., Malone, R.E. Genetics (1996) [Pubmed]
  8. Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis. Friedman, D.B., Hollingsworth, N.M., Byers, B. Genetics (1994) [Pubmed]
  9. A conditional allele of the Saccharomyces cerevisiae HOP1 gene is suppressed by overexpression of two other meiosis-specific genes: RED1 and REC104. Hollingsworth, N.M., Johnson, A.D. Genetics (1993) [Pubmed]
  10. Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway. Schwacha, A., Kleckner, N. Cell (1997) [Pubmed]
  11. Expression and DNA sequence of RED1, a gene required for meiosis I chromosome segregation in yeast. Thompson, E.A., Roeder, G.S. Mol. Gen. Genet. (1989) [Pubmed]
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