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Gene Review

NOP7  -  Nop7p

Saccharomyces cerevisiae S288c

Synonyms: Nucleolar protein 7, Pescadillo homolog, RRP13, Ribosomal RNA-processing protein 13, YGR103W, ...
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High impact information on NOP7


Biological context of NOP7

  • Two clones were identified encoding a segment of YPH1 (yeast pescadillo homolog), which is essential for cell cycle progression in yeast [2].
  • Deletion analysis revealed that the catalytic domain of Yvh1p and the BRCT domain of Yph1p are sufficient for this interaction [2].

Anatomical context of NOP7

  • The temperature-sensitive nop7-1 mutation or metabolic depletion of Nop7p results in a deficiency of 60S ribosomal subunits and accumulation of halfmer polyribosomes [3].

Regulatory relationships of NOP7

  • We found that the multicopy of YPH1 not only suppressed slow growth but also decreased IME2 expression in the yvh1 disruptant [2].

Other interactions of NOP7

  • Thus Nop7p, like Drs1p, is required for essential steps leading to synthesis of 60S ribosomal subunits [3].
  • Nop7p is localized primarily in the nucleolus, where most steps in ribosome assembly occur [3].
  • Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes [4].
  • However, Nop7 and Erb1 assemble into preribosomes prior to Ytm1 [4].
  • Depletion of Nop7p leads to nuclear accumulation of pre-60S particles, indicating a defect in subunit export, and it interacts genetically with a tagged form of the ribosomal protein Rpl25p, consistent with a role in subunit assembly [5].

Analytical, diagnostic and therapeutic context of NOP7

  • Immunoprecipitation of the origin recognition complex (ORC) from yeast extracts identified Yph1p, an essential protein containing a BRCT domain [1].


  1. Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Du, Y.C., Stillman, B. Cell (2002) [Pubmed]
  2. Dual-specificity protein phosphatase Yvh1p, which is required for vegetative growth and sporulation, interacts with yeast pescadillo homolog in Saccharomyces cerevisiae. Sakumoto, N., Yamashita, H., Mukai, Y., Kaneko, Y., Harashima, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. Adams, C.C., Jakovljevic, J., Roman, J., Harnpicharnchai, P., Woolford, J.L. RNA (2002) [Pubmed]
  4. Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Miles, T.D., Jakovljevic, J., Horsey, E.W., Harnpicharnchai, P., Tang, L., Woolford, J.L. Mol. Cell. Biol. (2005) [Pubmed]
  5. Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis. Oeffinger, M., Leung, A., Lamond, A., Tollervey, D., Lueng, A. RNA (2002) [Pubmed]
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