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Gene Review

ULP2  -  Ulp2p

Saccharomyces cerevisiae S288c

Synonyms: SMT4, Ubiquitin-like-specific protease 2, YIL031W
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Disease relevance of ULP2


High impact information on ULP2

  • The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II [3].
  • Yeast has two SUMO-1-deconjugating enzymes, Ulp1 and Ulp2, which are located at nuclear pores and in the nucleoplasm, respectively [4].
  • Like SMT3, SMT4 was first isolated as a high-copy-number suppressor of a defective centromere-binding protein [5].
  • Deletion of the Ulp2 SUMO protease failed to restore ubc9-10 cell resistance to Top1p poisons or hydroxyurea yet adversely affected wild-type TOP1 cell genetic stability and sensitivity to hydroxyurea [6].
  • Three other interacting proteins, Mgs1p, Ulp2, and Plp2, participate in chromosome assembling and segregation, whereas the function of two others has not been established [7].

Biological context of ULP2


Associations of ULP2 with chemical compounds

  • Remarkably, NH2-terminally deleted Ulp1 variants are able, unlike full-length Ulp1, to suppress defects of cells lacking the divergent Ulp2 isopeptidase [8].

Other interactions of ULP2

  • The previously uncharacterized SIZ1 (SAP and Miz) gene, which encodes a protein containing a predicted DNA-binding SAP module and a Miz finger, is identified as a bypass suppressor of the growth defect associated with the SMT4 disruption [2].
  • A disruption allele of SMT4 has a prominent chromosome phenotype: impaired targeting of Smc4p-GFP to rDNA chromatin [2].


  1. SUMO conjugation and deconjugation. Schwienhorst, I., Johnson, E.S., Dohmen, R.J. Mol. Gen. Genet. (2000) [Pubmed]
  2. Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Strunnikov, A.V., Aravind, L., Koonin, E.V. Genetics (2001) [Pubmed]
  3. The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Bachant, J., Alcasabas, A., Blat, Y., Kleckner, N., Elledge, S.J. Mol. Cell (2002) [Pubmed]
  4. Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Panse, V.G., Küster, B., Gerstberger, T., Hurt, E. Nat. Cell Biol. (2003) [Pubmed]
  5. The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Li, S.J., Hochstrasser, M. Mol. Cell. Biol. (2000) [Pubmed]
  6. Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage. Jacquiau, H.R., van Waardenburg, R.C., Reid, R.J., Woo, M.H., Guo, H., Johnson, E.S., Bjornsti, M.A. J. Biol. Chem. (2005) [Pubmed]
  7. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Wysocka, M., Rytka, J., Kurlandzka, A. Exp. Cell Res. (2004) [Pubmed]
  8. The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. Li, S.J., Hochstrasser, M. J. Cell Biol. (2003) [Pubmed]
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