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PCL2  -  Pcl2p

Saccharomyces cerevisiae S288c

Synonyms: CLN4, Cyclin HCS26 homolog, D2223, G1/S-specific cyclin PCL2, PHO85 cyclin-2, ...
 
 
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High impact information on PCL2

 

Biological context of PCL2

  • We propose that the G1 cyclins encoded by PCL1 and PCL2 positively regulate CDC42 or another morphogenesis promoting function [5].
  • PCL2 is already known to be expressed in late G1 and we find that, in addition, it is also regulated by Swi5 in telophase [6].
  • The expression of PCL2 and PCL9 at this stage of the cell cycle implies a role for the Pho85 Cdk at the end of mitosis [6].
  • This pattern of regulation is different from PCL1 and PCL2, which are expressed later in G1 phase and are regulated primarily by the transcription factor SBF [7].
 

Physical interactions of PCL2

  • We identified a gene with a Swi5-binding site in the promoter that encoded a protein with high homology to Pcl2, a cyclin-like protein that associates with the Cdk Pho85 [6].
 

Other interactions of PCL2

  • In contrast, deletion of PCL2, the closest relative of PCL9, had no effect on the budding pattern [7].
  • Fus3p and Kss1p together increase the expression of CLN3 and PCL2 genes that promote budding, and Kss1p inhibits the MAP kinase cascade [8].
  • Previous work has shown that Rvs167p can be phosphorylated in vitro by the cyclin-dependent kinase Pho85p complexed with its cyclin Pcl2p [4].
 

Analytical, diagnostic and therapeutic context of PCL2

  • We performed both biochemical and genetic tests to discover the biological significance of the interaction between Pcl2 and Swi5 seen in the two-hybrid assay [9].

References

  1. The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Measday, V., Moore, L., Ogas, J., Tyers, M., Andrews, B. Science (1994) [Pubmed]
  2. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Baetz, K., Moffat, J., Haynes, J., Chang, M., Andrews, B. Mol. Cell. Biol. (2001) [Pubmed]
  3. A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Measday, V., Moore, L., Retnakaran, R., Lee, J., Donoviel, M., Neiman, A.M., Andrews, B. Mol. Cell. Biol. (1997) [Pubmed]
  4. Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation. Friesen, H., Murphy, K., Breitkreutz, A., Tyers, M., Andrews, B. Mol. Biol. Cell (2003) [Pubmed]
  5. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Lenburg, M.E., O'Shea, E.K. Genetics (2001) [Pubmed]
  6. Swi5 controls a novel wave of cyclin synthesis in late mitosis. Aerne, B.L., Johnson, A.L., Toyn, J.H., Johnston, L.H. Mol. Biol. Cell (1998) [Pubmed]
  7. A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae. Tennyson, C.N., Lee, J., Andrews, B.J. Mol. Microbiol. (1998) [Pubmed]
  8. Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p. Cherkasova, V., Lyons, D.M., Elion, E.A. Genetics (1999) [Pubmed]
  9. Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast. Measday, V., McBride, H., Moffat, J., Stillman, D., Andrews, B. Mol. Microbiol. (2000) [Pubmed]
 
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