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NDE2  -  NADH-ubiquinone reductase (H(+)...

Saccharomyces cerevisiae S288c

Synonyms: External NADH dehydrogenase 2, External NADH-ubiquinone oxidoreductase 2, mitochondrial, NDH2, YDL085W
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High impact information on NDE2

  • Mitochondria isolated from COQ7-deficient cells secreted more than 30 times as much H(2)O(2) at 42 as at 30 degrees C, while mitochondria isolated from cells simultaneously deficient in NDE1 and NDE2 secreted no H(2)O(2) [1].
  • In contrast, deletion of the external NADH dehydrogenases NDE1 and NDE2, which feed electrons from NADH into the electron transport chain, abrogated the levels of heat-induced intracellular fluorescence and nuclear mutation frequency [1].
  • In the yeast Saccharomyces cerevisiae, the most important systems for conveying excess cytosolic NADH to the mitochondrial respiratory chain are the external NADH dehydrogenases (Nde1p and Nde2p) and the glycerol-3-phosphate dehydrogenase shuttle [2].
  • Studies on the functionally isolated enzymes demonstrated that neither Nde1p nor Nde2p directly inhibits Gut2p [2].

Biological context of NDE2


Associations of NDE2 with chemical compounds


Other interactions of NDE2

  • The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH [5].


  1. Mitochondrial respiratory electron carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae. Davidson, J.F., Schiestl, R.H. Mol. Cell. Biol. (2001) [Pubmed]
  2. Competition of electrons to enter the respiratory chain: a new regulatory mechanism of oxidative metabolism in Saccharomyces cerevisiae. Bunoust, O., Devin, A., Avéret, N., Camougrand, N., Rigoulet, M. J. Biol. Chem. (2005) [Pubmed]
  3. Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae. Påhlman, I.L., Larsson, C., Averét, N., Bunoust, O., Boubekeur, S., Gustafsson, L., Rigoulet, M. J. Biol. Chem. (2002) [Pubmed]
  4. Metabolic engineering of glycerol production in Saccharomyces cerevisiae. Overkamp, K.M., Bakker, B.M., Kötter, P., Luttik, M.A., Van Dijken, J.P., Pronk, J.T. Appl. Environ. Microbiol. (2002) [Pubmed]
  5. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. Luttik, M.A., Overkamp, K.M., Kötter, P., de Vries, S., van Dijken, J.P., Pronk, J.T. J. Biol. Chem. (1998) [Pubmed]
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