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Gene Review

CAT5  -  putative monooxygenase CAT5

Saccharomyces cerevisiae S288c

Synonyms: COQ7, Catabolite repression protein CAT5, Coenzyme Q biosynthesis protein 7, O3284, Ubiquinone biosynthesis protein COQ7, ...
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Disease relevance of CAT5


High impact information on CAT5

  • Deletion of CAT5 caused a complete loss of glucose derepression affecting gluconeogenic key enzymes [2].
  • The CAT5 gene is necessary for UAS1PCK1 and UAS2PCK1 protein binding since a carbon source-specific interaction was no longer detectable in cat5 mutants [2].
  • By screening for mutants that failed to derepress a UAS2PCK1-CYC1-lacZ reporter gene we isolated the new recessive derepression mutation cat5 [2].
  • Mitochondria isolated from COQ7-deficient cells secreted more than 30 times as much H(2)O(2) at 42 as at 30 degrees C, while mitochondria isolated from cells simultaneously deficient in NDE1 and NDE2 secreted no H(2)O(2) [3].
  • Here we show that addition of Q to the growth media also stabilizes the Coq3 and Coq4 polypeptides in the coq7 null mutant [1].

Chemical compound and disease context of CAT5


Biological context of CAT5


Anatomical context of CAT5

  • CAT5 functions as a high-affinity, basic amino acid transporter at the plasma membrane [8].
  • Morphological studies showed that COQ7-deficient neuroepithelial cells failed to show the radial arrangement in the developing cerebral wall, aborting neurogenesis at E10 [5].

Associations of CAT5 with chemical compounds


Other interactions of CAT5

  • The ubiF gene encodes a flavin-dependent monooxygenase that shares no homology to the Coq7 protein and is required for the final monooxygenase step of Q biosynthesis in E. coli [1].
  • The expression profiles suggest that CAT5 may function in reuptake of leaking amino acids at the leaf margin, while CAT8 is expressed in young and rapidly dividing tissues such as young leaves and root apical meristem [8].

Analytical, diagnostic and therapeutic context of CAT5


  1. Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. Tran, U.C., Marbois, B., Gin, P., Gulmezian, M., Jonassen, T., Clarke, C.F. J. Biol. Chem. (2006) [Pubmed]
  2. CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. Proft, M., Kötter, P., Hedges, D., Bojunga, N., Entian, K.D. EMBO J. (1995) [Pubmed]
  3. Mitochondrial respiratory electron carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae. Davidson, J.F., Schiestl, R.H. Mol. Cell. Biol. (2001) [Pubmed]
  4. Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. Padilla, S., Jonassen, T., Jiménez-Hidalgo, M.A., Fernández-Ayala, D.J., López-Lluch, G., Marbois, B., Navas, P., Clarke, C.F., Santos-Ocaña, C. J. Biol. Chem. (2004) [Pubmed]
  5. Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis. Nakai, D., Yuasa, S., Takahashi, M., Shimizu, T., Asaumi, S., Isono, K., Takao, T., Suzuki, Y., Kuroyanagi, H., Hirokawa, K., Koseki, H., Shirsawa, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans. Takahashi, M., Asaumi, S., Honda, S., Suzuki , Y., Nakai, D., Kuroyanagi, H., Shimizu, T., Honda, Y., Shirasawa, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. Jonassen, T., Marbois, B.N., Kim, L., Chin, A., Xia, Y.R., Lusis, A.J., Clarke, C.F. Arch. Biochem. Biophys. (1996) [Pubmed]
  8. Molecular and functional characterization of a family of amino acid transporters from Arabidopsis. Su, Y.H., Frommer, W.B., Ludewig, U. Plant Physiol. (2004) [Pubmed]
  9. The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis. Marbois, B.N., Clarke, C.F. J. Biol. Chem. (1996) [Pubmed]
  10. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. Santos-Ocaña, C., Do, T.Q., Padilla, S., Navas, P., Clarke, C.F. J. Biol. Chem. (2002) [Pubmed]
  11. Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. Asaumi, S., Kuroyanagi, H., Seki, N., Shirasawa, T. Genomics (1999) [Pubmed]
  12. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. Vajo, Z., King, L.M., Jonassen, T., Wilkin, D.J., Ho, N., Munnich, A., Clarke, C.F., Francomano, C.A. Mamm. Genome (1999) [Pubmed]
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