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Gene Review

VAM6  -  Vam6p

Saccharomyces cerevisiae S288c

Synonyms: CVT4, VPL18, VPL22, VPS39, Vacuolar morphogenesis protein 6, ...
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High impact information on VAM6

  • The COOH-terminal 148 amino acids of Vps39 direct its association with the class C-Vps complex by binding to Vps11 [1].
  • Like other VAM-encoded proteins, which are needed for homotypic vacuole fusion, we now report that Vam2p and its associated protein Vam6p/Vps39p are needed on each vacuole partner for homotypic fusion [2].
  • We propose that the class C-Vps complex both promotes Vps39-dependent nucleotide exchange on Ypt7 and, based on the work of Price et al., acts as a Ypt7 effector that tethers transport vesicles to the vacuole [1].
  • However, disruption of YDL077c (also known as VAM6) exhibited an slow growth phenotype in minimal media and also in rich media containing glycerol as a carbon source [3].
  • We report here the identification and characterization of a novel protein in Aspergillus nidulans, AvaB, that exhibits similarity to Vam6p/Vps39p and plays a critical role in vacuolar morphogenesis in A. nidulans [4].

Biological context of VAM6


Anatomical context of VAM6

  • Deletion of the VAM2 and VAM6 functions resulted in accumulation of numerous vacuole-related structures of 200-400 nm in diameter that were much smaller than the normal vacuoles [5].

Analytical, diagnostic and therapeutic context of VAM6


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