The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

DIN7  -  Din7p

Saccharomyces cerevisiae S288c

Synonyms: DIN3, DNA damage-inducible protein DIN7, YD9320B.02C, YDR263C
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on DIN7

  • This frequency was unaffected by deletion of several DNA mismatch repair genes or deletion of the EXO1 and DIN7 genes and was not enhanced through meiosis in a wild-type background [1].
  • The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondria [2].
  • We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication [2].
  • A possible mechanism that may be responsible for the decreased stability of the mitochondrial genome in S. cerevisiae cells with elevated levels of Din7p is discussed [2].
  • The frequencies of chromosomal mutations conferring resistance to canavanine (Can(r)) or adenine prototrophy (Ade(+)) are not affected by enhanced synthesis of Din7p [2].
 

Biological context of DIN7

  • We show that the expression level of DIN7 rises during meiosis at a time nearly coincident with commitment to recombination [3].
  • The DNA sequence of DIN7 was determined [3].
  • The expression of the DIN7 gene was studied in detail using a DIN7-lacZ fusion integrated into a chromosome [3].
  • We suggest that a form of Dun1 may be a negative regulator of the DIN7 gene expression [3].
  • We reported previously that overexpression of DIN7 results in a mitochondrial mutator phenotype [4].
 

Associations of DIN7 with chemical compounds

  • In the present study we describe isolation of a novel gene, Din7, the expression of which is induced by exposure of cells to UV light, MMS (methyl methane-sulfonate) or HU (hydoxyurea) [3].
 

Other interactions of DIN7

 

Analytical, diagnostic and therapeutic context of DIN7

References

 
WikiGenes - Universities