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Gene Review

DIN7  -  Din7p

Saccharomyces cerevisiae S288c

Synonyms: DIN3, DNA damage-inducible protein DIN7, YD9320B.02C, YDR263C
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High impact information on DIN7

  • This frequency was unaffected by deletion of several DNA mismatch repair genes or deletion of the EXO1 and DIN7 genes and was not enhanced through meiosis in a wild-type background [1].
  • The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondria [2].
  • We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication [2].
  • A possible mechanism that may be responsible for the decreased stability of the mitochondrial genome in S. cerevisiae cells with elevated levels of Din7p is discussed [2].
  • The frequencies of chromosomal mutations conferring resistance to canavanine (Can(r)) or adenine prototrophy (Ade(+)) are not affected by enhanced synthesis of Din7p [2].

Biological context of DIN7

  • We show that the expression level of DIN7 rises during meiosis at a time nearly coincident with commitment to recombination [3].
  • The DNA sequence of DIN7 was determined [3].
  • The expression of the DIN7 gene was studied in detail using a DIN7-lacZ fusion integrated into a chromosome [3].
  • We suggest that a form of Dun1 may be a negative regulator of the DIN7 gene expression [3].
  • We reported previously that overexpression of DIN7 results in a mitochondrial mutator phenotype [4].

Associations of DIN7 with chemical compounds

  • In the present study we describe isolation of a novel gene, Din7, the expression of which is induced by exposure of cells to UV light, MMS (methyl methane-sulfonate) or HU (hydoxyurea) [3].

Other interactions of DIN7


Analytical, diagnostic and therapeutic context of DIN7


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