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Gene Review

HIM1  -  Him1p

Saccharomyces cerevisiae S288c

Synonyms: High induction of mutagenesis protein 1, Protein HIM1, YDR317W
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High impact information on HIM1

  • Hsk1 and Dfp1/Him1 both co-immunoprecipitate with Swi1 [1].
  • To elucidate the role of the HIM1 in control of spontaneous mutagenesis, we checked the repair of DNA mispaired bases in the him1 mutant and discovered that it was not altered in comparison to the wild-type strain [2].
  • We have identified a new Saccharomyces cerevisiae gene, HIM1, mapped on the right arm of the chromosome IV (ORF YDR317w), mutations in which led to an increase in spontaneous mutation rate and elevated the frequencies of mutations, induced by UV-light, nitrous acid, ethylmethane sulfonate and methylmethane sulfonate [2].
  • In our opinion, our results suggest that HIM1 gene participates in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage [2].
  • Spontaneous mitotic gene conversion at the ADE2 locus is altered in him1 strains, either increased or decreased, depending on the particular heteroallelic combination [3].

Biological context of HIM1


Other interactions of HIM1

  • Here we describe physical and genetic interactions involving Swi1 and Hsk1-Dfp1/Him1 [1].

Analytical, diagnostic and therapeutic context of HIM1

  • The latter agent revealed the most apparent differences between the him mutants and the wild-type strain and was, therefore, chosen for the genetic analysis of mutants, him mutations analyzed behaved as a single Mendelian trait; complementation tests indicated 3 complementation groups (HIM1, HIM2, and HIM3), each containing 1 mutant allele [3].


  1. Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P., Masai, H. J. Biol. Chem. (2005) [Pubmed]
  2. HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis. Kelberg, E.P., Kovaltsova, S.V., Alekseev, S.Y., Fedorova, I.V., Gracheva, L.M., Evstukhina, T.A., Korolev, V.G. Mutat. Res. (2005) [Pubmed]
  3. Saccharomyces cerevisiae mutants with enhanced induced mutation and altered mitotic gene conversion. Ivanov, E.L., Kovaltzova, S.V., Korolev, V.G. Mutat. Res. (1989) [Pubmed]
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