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Gene Review

SBE2  -  Sbe2p

Saccharomyces cerevisiae S288c

Synonyms: D9476.7, Protein SBE2, Suppressor of BEM4 protein 2, YDR351W
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High impact information on SBE2

  • Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation [1].
  • We have identified and characterized two homologous yeast proteins, Sbe2p and Sbe22p, through their suppression of a chs5 spa2 mutant strain defective in chitin synthesis and cell morphogenesis [1].
  • Finally, immunofluorescence experiments reveal that in small-budded cells, sbe2 sbe22 mutants mislocalize Chs3p, a protein involved in chitin synthesis [1].
  • Second, electron microscopic analysis reveals that sbe2 sbe22 cells have an aberrant cell wall structure with a reduced mannoprotein layer [1].
  • In addition, sbe2 sbe22 diploids have a bud-site selection defect, displaying a random budding pattern [1].

Biological context of SBE2


Anatomical context of SBE2

  • SBE2 has been described in S. cerevisiae to encode a Golgi protein involved in the transport of cell wall components (B. Santos and M. Snyder, Mol. Biol. Cell, 11:435-452, 2000) [2].
  • Thus, we suggest a model in which Sbe2p and Sbe22p are involved in the transport of cell wall components from the Golgi apparatus to the cell surface periphery in a pathway independent of Chs5p [1].

Regulatory relationships of SBE2

  • In conclusion, overexpression of Sbe2p under the regulated control of the GAL1 promoter results in caspofungin resistance in S. cerevisiae [2].


  1. Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation. Santos, B., Snyder, M. Mol. Biol. Cell (2000) [Pubmed]
  2. Overexpression of Sbe2p, a Golgi protein, results in resistance to caspofungin in Saccharomyces cerevisiae. Osherov, N., May, G.S., Albert, N.D., Kontoyiannis, D.P. Antimicrob. Agents Chemother. (2002) [Pubmed]
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