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Gene Review:

Kpna2 - karyopherin alpha 2

Rattus norvegicus

Albermann, L. et al., Pickard, B.W. et al., Perlson, E. et al., Cassany, A. et al., Hearps, A.C. et al.

Albermann, Shahin, Ludwig, Schäfer, Schillers, Oberleithner,

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Disease relevance of Kpna2

HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism [1].

High impact information on Kpna2

Vimentin binds phosphorylated Erks (pErk), thus linking pErk to the dynein retrograde motor via direct binding of vimentin to importin beta [2].
We studied the role of the karyopherin alpha2 nuclear import carrier (also known as importin alpha2) in glucose signaling [3].
Evidence for importin alpha independent nuclear translocation of glucocorticoid receptors in Xenopus laevis oocytes [4].

Analytical, diagnostic and therapeutic context of Kpna2

Also, using an anti-importin beta antibody, Western blots detected importin beta at 94 kDa [5].
Using immunoprecipitation and affinity chromatography, we show that the PTH1R forms a complex with the importin family of transport molecules [5].

References

HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Hearps, A.C., Jans, D.A. Biochem. J. (2006) [Pubmed]
Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Perlson, E., Hanz, S., Ben-Yaakov, K., Segal-Ruder, Y., Seger, R., Fainzilber, M. Neuron (2005) [Pubmed]
A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells. Cassany, A., Guillemain, G., Klein, C., Dalet, V., Brot-Laroche, E., Leturque, A. Traffic (2004) [Pubmed]
Evidence for importin alpha independent nuclear translocation of glucocorticoid receptors in Xenopus laevis oocytes. Albermann, L., Shahin, V., Ludwig, Y., Schäfer, C., Schillers, H., Oberleithner, H. Cell. Physiol. Biochem. (2004) [Pubmed]
Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta. Pickard, B.W., Hodsman, A.B., Fraher, L.J., Watson, P.H. Endocrinology (2006) [Pubmed]

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AgaP_AGAP009792	Anopheles gambiae str. PEST
KPNA2	Bos taurus
KPNA2	Canis lupus familiaris
kpna2	Danio rerio
Pen	Drosophila melanogaster
KPNA2	Gallus gallus
KPNA2	Homo sapiens
KPNA2	Macaca mulatta
Kpna2	Mus musculus
KPNA2	Pan troglodytes
LOC100359600	Rattus norvegicus
kpna2	Xenopus (Silurana) tropicalis

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