The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Vim  -  vimentin

Mus musculus

Synonyms: Vimentin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Vim


Psychiatry related information on Vim


High impact information on Vim

  • While these results leave open the question of the possible role of vimentin in unusual situations or pathological conditions, they show that a conspicuous developmental and cell-specific structure that is an integral part of the cytoskeleton can be eliminated without apparent effect on mouse reproduction and development [8].
  • Mice lacking vimentin develop and reproduce without an obvious phenotype [8].
  • To address the biological role of vimentin in the context of the living organism, we have introduced a null mutation of the vimentin gene into the germ line of mice [8].
  • Localization of newly synthesized vimentin subunits reveals a novel mechanism of intermediate filament assembly [9].
  • During adipose conversion of murine 3T3-L1 cells, the arrangement of vimentin intermediate filaments (IFs) changes from an extended fibrillar state to a complex cage formation tightly associated with the forming lipid globules [10].

Chemical compound and disease context of Vim


Biological context of Vim


Anatomical context of Vim


Associations of Vim with chemical compounds


Physical interactions of Vim


Enzymatic interactions of Vim


Co-localisations of Vim


Regulatory relationships of Vim


Other interactions of Vim

  • In embryonic stages, E9-12, anti-ELF localized to the primary brain vesicular cells that also labeled strongly with anti-nestin but not anti-vimentin [40].
  • The co-expression of mesenchymal marker alpha-smooth muscle (alpha-SMA), fibronectin and vimentin with E-cadherin in these dermal cells was further examined [41].
  • Further analysis revealed several domains of significant similarity (50%) between all alpha-helices of the rod domain of vimentin and the N-terminal (approximately 210 residues) activation domain tpr of the oncogenic raf [18].
  • K8, K19, and vimentin were undetectable in both lines [42].
  • No differences were observed in E-cadherin and vimentin immunostain in palatal epithelium between the strains [43].

Analytical, diagnostic and therapeutic context of Vim


  1. Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Shu, Q., Antalffy, B., Su, J.M., Adesina, A., Ou, C.N., Pietsch, T., Blaney, S.M., Lau, C.C., Li, X.N. Clin. Cancer Res. (2006) [Pubmed]
  2. Relationships between intermediate filaments and cell-specific functions in renal cell lines derived from transgenic mice harboring the temperature-sensitive T antigen. Cluzeaud, F., Bens, M., Wu, M.S., Li, Z., Vicart, P., Paulin, D., Vandewalle, A. J. Cell. Physiol. (1996) [Pubmed]
  3. Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance. Terzi, F., Henrion, D., Colucci-Guyon, E., Federici, P., Babinet, C., Levy, B.I., Briand, P., Friedlander, G. J. Clin. Invest. (1997) [Pubmed]
  4. Recovery of Na-glucose cotransport activity after renal ischemia is impaired in mice lacking vimentin. Runembert, I., Couette, S., Federici, P., Colucci-Guyon, E., Babinet, C., Briand, P., Friedlander, G., Terzi, F. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  5. Transcriptional regulation of the vimentin-encoding gene in mouse myeloid leukemia M1 cells. Nakamura, N., Shida, M., Hirayoshi, K., Nagata, K. Gene (1995) [Pubmed]
  6. A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice. Bornheim, R., Müller, M., Reuter, U., Herrmann, H., Büssow, H., Magin, T.M. J. Cell. Sci. (2008) [Pubmed]
  7. Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. Yen, S.H., Gaskin, F., Fu, S.M. Am. J. Pathol. (1983) [Pubmed]
  8. Mice lacking vimentin develop and reproduce without an obvious phenotype. Colucci-Guyon, E., Portier, M.M., Dunia, I., Paulin, D., Pournin, S., Babinet, C. Cell (1994) [Pubmed]
  9. Localization of newly synthesized vimentin subunits reveals a novel mechanism of intermediate filament assembly. Ngai, J., Coleman, T.R., Lazarides, E. Cell (1990) [Pubmed]
  10. Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Franke, W.W., Hergt, M., Grund, C. Cell (1987) [Pubmed]
  11. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cos, S., Fernández, R., Güézmes, A., Sánchez-Barceló, E.J. Cancer Res. (1998) [Pubmed]
  12. PKC mediates 12(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells. Timar, J., Tang, D., Bazaz, R., Haddad, M.M., Kimler, V.A., Taylor, J.D., Honn, K.V. Cell Motil. Cytoskeleton (1993) [Pubmed]
  13. Differentiation of murine erythroleukemia cells results in the rapid repression of vimentin gene expression. Ngai, J., Capetanaki, Y.G., Lazarides, E. J. Cell Biol. (1984) [Pubmed]
  14. An in vivo study of the role of the tumor cell cytoskeleton in tumor cell-platelet-endothelial cell interactions. Chopra, H., Fligiel, S.E., Hatfield, J.S., Nelson, K.K., Diglio, C.A., Taylor, J.D., Honn, K.V. Cancer Res. (1990) [Pubmed]
  15. Effect of the ionic environment on the incorporation of the intermediate-sized filament protein vimentin into residual cell structures upon treatment of Ehrlich ascites tumour cells with triton X-100. I. Biochemical analysis. Traub, P., Nelson, W.J. J. Cell. Sci. (1982) [Pubmed]
  16. Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. Li, Z., Mericskay, M., Agbulut, O., Butler-Browne, G., Carlsson, L., Thornell, L.E., Babinet, C., Paulin, D. J. Cell Biol. (1997) [Pubmed]
  17. Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly. Fürst, D.O., Osborn, M., Weber, K. J. Cell Biol. (1989) [Pubmed]
  18. Mouse vimentin: structural relationship to fos, jun, CREB and tpr. Capetanaki, Y., Kuisk, I., Rothblum, K., Starnes, S. Oncogene (1990) [Pubmed]
  19. Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. Lundkvist, A., Reichenbach, A., Betsholtz, C., Carmeliet, P., Wolburg, H., Pekny, M. J. Cell. Sci. (2004) [Pubmed]
  20. Vimentin expression is differentially regulated by IL-2 and IL-4 in murine T cells. Hornbeck, P.V., Garrels, J.I., Capetanaki, Y., Heimer, S. J. Immunol. (1993) [Pubmed]
  21. Intermediate filament protein partnership in astrocytes. Eliasson, C., Sahlgren, C., Berthold, C.H., Stakeberg, J., Celis, J.E., Betsholtz, C., Eriksson, J.E., Pekny, M. J. Biol. Chem. (1999) [Pubmed]
  22. Expression of glial fibrillary acidic protein and vimentin in mouse lens epithelial cells during development in vivo and during proliferation and differentiation in vitro: comparison with the developmental appearance of GFAP in the mouse central nervous system. Boyer, S., Maunoury, R., Gomès, D., de Néchaud, B., Hill, A.M., Dupouey, P. J. Neurosci. Res. (1990) [Pubmed]
  23. Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin. Ding, M., Eliasson, C., Betsholtz, C., Hamberger, A., Pekny, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  24. A new in vitro model of murine mesoderm migration: the role of fibronectin and laminin. Klinowska, T.C., Ireland, G.W., Kimber, S.J. Differentiation (1994) [Pubmed]
  25. The intermediate filament protein vimentin is a new target for epigallocatechin gallate. Ermakova, S., Choi, B.Y., Choi, H.S., Kang, B.S., Bode, A.M., Dong, Z. J. Biol. Chem. (2005) [Pubmed]
  26. Heat-shock and cadmium chloride increase the vimentin mRNA and protein levels in U-937 human promonocytic cells. Vilaboa, N.E., García-Bermejo, L., Pérez, C., de Blas, E., Calle, C., Aller, P. J. Cell. Sci. (1997) [Pubmed]
  27. Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry. Nahm, D.H., Tkaczyk, C., Fukuishi, N., Colucci-Guyon, E., Gilfillan, A.M., Metcalfe, D.D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  28. Integrating the actin and vimentin cytoskeletons. adhesion-dependent formation of fimbrin-vimentin complexes in macrophages. Correia, I., Chu, D., Chou, Y.H., Goldman, R.D., Matsudaira, P. J. Cell Biol. (1999) [Pubmed]
  29. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. Goto, H., Yasui, Y., Kawajiri, A., Nigg, E.A., Terada, Y., Tatsuka, M., Nagata, K., Inagaki, M. J. Biol. Chem. (2003) [Pubmed]
  30. PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells. Benítez-King, G. J. Pineal Res. (2000) [Pubmed]
  31. Matrix assisted laser desorption/ionization-time of flight-mass spectrometry analysis of proteins detected by anti-phosphotyrosine antibody on two-dimensional-gels of fibrolast cell lysates after tumor necrosis factor-alpha stimulation. Yanagida, M., Miura, Y., Yagasaki, K., Taoka, M., Isobe, T., Takahashi, N. Electrophoresis (2000) [Pubmed]
  32. Vimentin phosphorylation by p37mos protein kinase in vitro and generation of a 50-kDa cleavage product in v-mos-transformed cells. Singh, B., Arlinghaus, R.B. Virology (1989) [Pubmed]
  33. Tissue-specific expression of a vimentin--desmin hybrid gene in transgenic mice. Krimpenfort, P.J., Schaart, G., Pieper, F.R., Ramaekers, F.C., Cuypers, H.T., van den Heuvel, R.M., Vree Egberts, W.T., van Eys, G.J., Berns, A., Bloemendal, H. EMBO J. (1988) [Pubmed]
  34. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Humphrey, R.K., Bucay, N., Beattie, G.M., Lopez, A., Messam, C.A., Cirulli, V., Hayek, A. Diabetes (2003) [Pubmed]
  35. The cytoskeleton of isolated murine primitive erythrocytes. Koury, S.T., Repasky, E.A., Eckert, B.S. Cell Tissue Res. (1987) [Pubmed]
  36. Phenotypic modulation of keratins, vimentin, and alpha-fetoprotein in cultured rat liver epithelial cells after chemical, oncogene, and spontaneous transformation. Bisgaard, H.C., Ton, P.T., Nagy, P., Thorgeirsson, S.S. J. Cell. Physiol. (1994) [Pubmed]
  37. Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Zhao, M., Amiel, S.A., Christie, M.R., Rela, M., Heaton, N., Huang, G.C. Diabetologia (2005) [Pubmed]
  38. Co-expression of GFAP and vimentin in astrocytes proliferating in response to injury in the mouse cerebral hemisphere. A combined autoradiographic and double immunocytochemical study. Janeczko, K. Int. J. Dev. Neurosci. (1993) [Pubmed]
  39. Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. Sandilands, A., Wang, X., Hutcheson, A.M., James, J., Prescott, A.R., Wegener, A., Pekny, M., Gong, X., Quinlan, R.A. Exp. Eye Res. (2004) [Pubmed]
  40. ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene. Tang, Y., Katuri, V., Iqbal, S., Narayan, T., Wang, Z., Lu, R.S., Mishra, L., Mishra, B. Oncogene (2002) [Pubmed]
  41. Epithelial-mesenchymal transition occurs after epidermal development in mouse skin. Kong, W., Li, S., Liu, C., Bari, A.S., Longaker, M.T., Lorenz, H.P. Exp. Cell Res. (2006) [Pubmed]
  42. In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: insights into the role of keratin 17 in mouse keratinocytes. Troy, T.C., Turksen, K. J. Cell. Physiol. (1999) [Pubmed]
  43. Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting. Montenegro, M.A., Rojas, M., Dominguez, S., Vergara, A. J. Craniofac. Genet. Dev. Biol. (2000) [Pubmed]
  44. Chromosomal localization of the mouse gene coding for vimentin. Mattei, M.G., Lilienbaum, A., Lin, L.Z., Mattei, J.F., Paulin, D. Genet. Res. (1989) [Pubmed]
  45. Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts. Tolstonog, G.V., Shoeman, R.L., Traub, U., Traub, P. DNA Cell Biol. (2001) [Pubmed]
  46. Morphological analysis of glutaraldehyde-fixed vimentin intermediate filaments and assembly-intermediates by atomic force microscopy. Ando, S., Nakao, K., Gohara, R., Takasaki, Y., Suehiro, K., Oishi, Y. Biochim. Biophys. Acta (2004) [Pubmed]
WikiGenes - Universities