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Gene Review

Pth1r  -  parathyroid hormone 1 receptor

Rattus norvegicus

Synonyms: PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, PTHrel, Parathyroid hormone 1 receptor, ...
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Disease relevance of Pthr1


High impact information on Pthr1


Biological context of Pthr1


Anatomical context of Pthr1


Associations of Pthr1 with chemical compounds

  • Neither receptor can modify parathyroid hormone receptor-mediated elevation of cellular cyclic AMP [17].
  • The present study was performed to measure [Ca2+]i in renal cells, to estimate the concentrations of mRNA of the PTH-PTHrP receptor in kidney, liver, and heart, and to examine the phosphaturic response to PTH and adenine 3',5'-cyclic monophosphate (cAMP) in normal rats as well as in animals after 3 weeks of parathyroidectomy (PTX) [4].
  • In contrast, OP-1 treatment stimulated phenotypic differentiation in ROS 17/2.8 cells, as indicated by enhanced 1) alkaline phosphatase activity (4-fold); 2) alkaline phosphatase mRNA (5-fold); 3) parathyroid hormone receptor mRNA (2-fold), and 4) parathyroid hormone-stimulated adenosine 3',5'-cyclic monophosphate accumulation (2-fold) [18].

Regulatory relationships of Pthr1


Other interactions of Pthr1


Analytical, diagnostic and therapeutic context of Pthr1


  1. Effect of transforming growth factor beta on parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells. Seitz, P.K., Zhu, B.T., Cooper, C.W. J. Bone Miner. Res. (1992) [Pubmed]
  2. Impaired agonist-induced calcium signaling in hepatocytes from chronic renal failure rats. Massry, S.G., Klin, M., Ni, Z., Tian, J., Kedes, L., Smogorzewski, M. Kidney Int. (1995) [Pubmed]
  3. Downregulation of parathyroid hormone receptor gene expression and osteoblastic dysfunction associated with skeletal resistance to parathyroid hormone in a rat model of renal failure with low turnover bone. Iwasaki-Ishizuka, Y., Yamato, H., Nii-Kono, T., Kurokawa, K., Fukagawa, M. Nephrol. Dial. Transplant. (2005) [Pubmed]
  4. Parathyroidectomy does not affect mRNA of PTH-PTHrP receptor in kidney, liver, and heart. Smogorzewski, M., Marcinkowski, W., Zhang, G., Massry, S.G. American journal of nephrology. (1997) [Pubmed]
  5. Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks. Vander Molen, M.A., Rubin, C.T., McLeod, K.J., McCauley, L.K., Donahue, H.J. J. Biol. Chem. (1996) [Pubmed]
  6. Characterization of fully active biotinylated parathyroid hormone analogs. Application to fluorescence-activated cell sorting of parathyroid hormone receptor bearing cells. Abou-Samra, A.B., Freeman, M., Jüppner, H., Uneno, S., Segre, G.V. J. Biol. Chem. (1990) [Pubmed]
  7. Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta. Pickard, B.W., Hodsman, A.B., Fraher, L.J., Watson, P.H. Endocrinology (2006) [Pubmed]
  8. Down-regulation of PTH-PTHrP receptor of heart in CRF: role of [Ca2+]i. Smogorzewski, M., Tian, J., Massry, S.G. Kidney Int. (1995) [Pubmed]
  9. Distribution and pharmacokinetics of a potent peptide antagonist of parathyroid hormone and parathyroid hormone-related protein in the rat. Schetz, J.A., Mayr, C.A., Taylor, J.E., Rosenblatt, M., Chorev, M., Davis, T.P. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  10. Sequencing of eleven introns in genomic DNA encoding rat glucagon receptor and multiple alternative splicing of its mRNA. Maget, B., Tastenoy, M., Svoboda, M. FEBS Lett. (1994) [Pubmed]
  11. Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I. Kawane, T., Mimura, J., Fujii-Kuriyama, Y., Horiuchi, N. Arch. Biochem. Biophys. (2005) [Pubmed]
  12. Biochemical and morphological characterization of parathyroid hormone receptor binding to the rat osteosarcoma cell line UMR-106. Mitchell, J., Rouleau, M.F., Goltzman, D. Endocrinology (1990) [Pubmed]
  13. Spontaneous differentiation of mesenchymal stem cells obtained from fetal rat circulation. Naruse, K., Urabe, K., Mukaida, T., Ueno, T., Migishima, F., Oikawa, A., Mikuni-Takagaki, Y., Itoman, M. Bone (2004) [Pubmed]
  14. Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation. Damron, T.A., Horton, J.A., Naqvi, A., Loomis, R.M., Margulies, B.S., Strauss, J.A., Farnum, C.E., Spadaro, J.A. Radiat. Res. (2006) [Pubmed]
  15. Parathyroid hormone-parathyroid hormone related protein receptor messenger RNA is present in many tissues besides the kidney. Tian, J., Smogorzewski, M., Kedes, L., Massry, S.G. American journal of nephrology. (1993) [Pubmed]
  16. Static compressive loading reduces the mRNA expression of type II and X collagen in rat growth-plate chondrocytes during postnatal growth. Villemure, I., Chung, M.A., Seck, C.S., Kimm, M.H., Matyas, J.R., Duncan, N.A. Connect. Tissue Res. (2005) [Pubmed]
  17. Separate P2T and P2U purinergic receptors with similar second messenger signaling pathways in UMR-106 osteoblasts. Sistare, F.D., Rosenzweig, B.A., Contrera, J.G., Jordan, B. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  18. Osteogenic protein-1 enhances phenotypic expression in ROS 17/2.8 cells. Kitten, A.M., Lee, J.C., Olson, M.S. Am. J. Physiol. (1995) [Pubmed]
  19. Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells. McCauley, L.K., Beecher, C.A., Melton, M.E., Werkmeister, J.R., Jüppner, H., Abou-Samra, A.B., Segre, G.V., Rosol, T.J. Mol. Cell. Endocrinol. (1994) [Pubmed]
  20. Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells. Radeff, J.M., Singh, A.T., Stern, P.H. Cell. Signal. (2004) [Pubmed]
  21. Type I collagen substrate increases calcitonin and parathyroid hormone receptor-mediated signal transduction in UMR 106-06 osteoblast-like cells. Ikeda, K., Michelangeli, V.P., Martin, T.J., Findlay, D.M. J. Cell. Physiol. (1993) [Pubmed]
  22. PTH-PTHrP receptor mRNA is downregulated in chronic renal failure. Tian, J., Smogorzewski, M., Kedes, L., Massry, S.G. American journal of nephrology. (1994) [Pubmed]
  23. Immunoprecipitation of the parathyroid hormone receptor. Wright, B.S., Tyler, G.A., O'Brien, R., Caporale, L.H., Rosenblatt, M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. Molecular characterization of gene expression changes in ROS 17/2.8 cells cultured in diffusion chambers in vivo. Onyia, J.E., Hale, L.V., Miles, R.R., Cain, R.L., Tu, Y., Hulman, J.F., Hock, J.M., Santerre, R.F. Calcif. Tissue Int. (1999) [Pubmed]
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