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Gene Review:

SLI15 - Sli15p

Saccharomyces cerevisiae S288c

Synonyms: INCENP-related protein SLI15, Inner centromere protein-related protein SLI15, YBR1206, YBR156C

Kang, J. et al., Tanaka, T.U. et al., Sandall, S. et al., Pereira, G. et al., Kim, J.H. et al., et al.

Dan Rozelle,

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High impact information on SLI15

Elimination of the linkage between centromeres and microtubules mediated by Bir1-Sli15 phenocopies mutations that selectively cripple Ipl1 kinase activation [1].
A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension [1].
Ipl1 and Sli15 also bind to Dam1, a microtubule-binding protein required for mitotic spindle integrity and kinetochore function [2].
We have shown previously that Ipl1 and Sli15 are required for chromosome segregation in Saccharomyces cerevisiae [2].
Cdc14 dephosphorylation of Sli15 allows its association with the anaphase spindle [3].

Biological context of SLI15

These genetic and biochemical studies indicate that Sli15 associates with Ipl1 to promote its function in chromosome segregation [4].
The Ipl1-binding and -stimulating activities of Sli15 both reside within a region containing homology to the metazoan inner centromere protein (INCENP) [2].

Anatomical context of SLI15

Similar to Dam1, Ipl1 and Sli15 each bind to microtubules directly in vitro, and they are associated with yeast centromeric DNA in vivo [2].

Associations of SLI15 with chemical compounds

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections [5].

Regulatory relationships of SLI15

Cdc14 not only regulates mitotic exit but also modulates spindle midzone assembly through Sli15-Ipl1 [3].

Other interactions of SLI15

Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation [2].
Activation of Cdc14 by separase was sufficient for Sli15 dephosphorylation and relocalization [3].

Analytical, diagnostic and therapeutic context of SLI15

This raises the possibility that Ipl1-Sli15 facilitates bi-orientation by promoting turnover of kinetochore-SPB connections until traction of sister kinetochores toward opposite spindle poles creates tension in the surrounding chromatin [5].

References

A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Sandall, S., Severin, F., McLeod, I.X., Yates, J.R., Oegema, K., Hyman, A., Desai, A. Cell (2006) [Pubmed]
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. Kang, J., Cheeseman, I.M., Kallstrom, G., Velmurugan, S., Barnes, G., Chan, C.S. J. Cell Biol. (2001) [Pubmed]
Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Pereira, G., Schiebel, E. Science (2003) [Pubmed]
Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. Kim, J.H., Kang, J.S., Chan, C.S. J. Cell Biol. (1999) [Pubmed]
Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Tanaka, T.U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M.J., Nasmyth, K. Cell (2002) [Pubmed]

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