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Gene Review

CSH1  -  mannosylinositol phosphorylceramide...

Saccharomyces cerevisiae S288c

Synonyms: CSG1/SUR1 homolog 1, Mannosyl phosphorylinositol ceramide synthase CSH1, YBR1212, YBR161W
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High impact information on CSH1

  • In this study, we found that Csg1 and Csh1 are N-glycosylated with core-type and mannan-type structures, respectively [1].
  • Regulation of the Transport and Protein Levels of the Inositol Phosphorylceramide Mannosyltransferases Csg1 and Csh1 by the Ca2+-binding Protein Csg2 [1].
  • However, uncomplexed Csh1 cannot exit from the endoplasmic reticulum [1].
  • Thus, Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression [1].
  • Here we show that open reading frame YBR161w, renamed CSH1, is functionally homologous to CSG1 and that deletion of both genes abolishes MIPC and M(IP)2C synthesis without affecting protein mannosylation [2].

Biological context of CSH1


Anatomical context of CSH1

  • Further identification of the glycosylated residues suggests that both Csg1 and Csh1 exhibit membrane topology with their C termini in the cytosol and their mannosyltransferase domains in the lumen [1].

Associations of CSH1 with chemical compounds

  • To better understand the molecular basis of the Ca(2+)-induced growth defect in IPC-C-overaccumulating cells, we searched for genes whose overexpression restored Ca(2+) tolerance in a mutant lacking the IPC mannosyltransferases Csg1p and Csh1p [4].

Other interactions of CSH1


  1. Regulation of the Transport and Protein Levels of the Inositol Phosphorylceramide Mannosyltransferases Csg1 and Csh1 by the Ca2+-binding Protein Csg2. Uemura, S., Kihara, A., Iwaki, S., Inokuchi, J., Igarashi, Y. J. Biol. Chem. (2007) [Pubmed]
  2. Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids. Lisman, Q., Pomorski, T., Vogelzangs, C., Urli-Stam, D., de Cocq van Delwijnen, W., Holthuis, J.C. J. Biol. Chem. (2004) [Pubmed]
  3. Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p. Uemura, S., Kihara, A., Inokuchi, J., Igarashi, Y. J. Biol. Chem. (2003) [Pubmed]
  4. HOR7, a multicopy suppressor of the Ca2+-induced growth defect in sphingolipid mannosyltransferase-deficient yeast. Lisman, Q., Urli-Stam, D., Holthuis, J.C. J. Biol. Chem. (2004) [Pubmed]
  5. Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28. Baur, S., Becker, J., Li, Z., Niegemann, E., Wehner, E., Wolter, R., Brendel, M. Yeast (1995) [Pubmed]
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