Disease relevance of Gas7

• Here we report that Gas7 plays a key role in the morphological differentiation of PC12 preneuronal rat pheochromocytoma cells (PC12 cells) [1].
• Conversely, GAS7 overexpression in undifferentiated neuroblastoma cell cultures dramatically promotes neurite-like outgrowth [2].

High impact information on Gas7

• gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation [2].
• Using in situ hybridization and immunocytochemical analysis, we show that GAS7 expression occurs prominently in cerebellar Purkinje cells and that inhibition of production in terminally differentiating cultures of embryonic murine cerebellum impedes neurite outgrowth from maturing Purkinje cells [2].
• Conservation of Gas7 isoforms by alternative splicing in mammals is also considered [3].
• Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury [3].
• Immunohistochemistry reveals that Gas7 was expressed primarily in the pyramidal neurons of the hippocampus and was quickly attenuated before recovery in the CA3 area after kainate was administered [3].

Anatomical context of Gas7

• The growth arrest-specific gene 7 (Gas7) is expressed primarily in the brain and is necessary for the formation of neurite in cultured cerebellar preneurons [3].
• Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells [1].

References