High impact information on Gas7

• In retroviral transduction/transplantation assays, Hoxa7- and Hoxa9-deficient progenitors remained susceptible to transformation by MLL-GAS7, which activates MLL through a dimerization-dependent mechanism [1].
• Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth [2].
• The growth-arrest-specific gene, Gas7, is required for neurite outgrowth in cerebellar neurons [2].
• We propose that Gas7 localized near the plasma membrane induces the assembly of actin and the membrane outgrowth [2].
• Gas7 isoforms were discovered in murine brain by alternative splicing [3].

Biological context of Gas7

• Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo [4].
• The Gas 7 protein, which increased markedly during growth arrest of NIH3T3 cells and persisted transiently at high levels upon reentry of cells into the cell cycle, localized near the plasma membrane and selectively colocalized with microfilaments in membrane ruffles [2].
• While some differentiation enhancers protect PC12 cells against lethal insults, gas7 overexpression in PC12 cells did not protect against oxygen-glucose deprivation, the calcium ionophore A23187, or the nitric oxide donor sodium nitroprusside, suggesting that gas7 is not neuroprotective [5].

Anatomical context of Gas7

• We have observed high expression of the Gas7 protein in blastocysts that gradually decreased in the neurula stages [4].
• Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice [4].
• The gas7 protein potentiates NGF-mediated differentiation of PC12 cells [5].
• They also suggest that the FCH domain in Gas7 may participate in the development of lamellipodia, and the WW domain may participate in the fine-tuning of the filopodia [3].

Associations of Gas7 with chemical compounds

• The potential neuroprotective activity of gas7 against various neurotoxic insults was also assessed [5].

Analytical, diagnostic and therapeutic context of Gas7

• Biochemical studies and electron microscopy showed that both full-length Gas7 protein and its C-terminal region can promote actin assembly as well as the crosslinking of actin filaments [2].

References