The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

THI2  -  Thi2p

Saccharomyces cerevisiae S288c

Synonyms: PHO6, Thiamine biosynthesis regulatory protein, YBR1624, YBR240C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on THI2

  • Northern blot analysis demonstrated that THI6 gene expression is regulated at the mRNA level by intracellular thiamin pyrophosphate, a coenzyme form of thiamin, and that it requires the positive regulatory factors encoded by the THI2 and THI3 genes [1].
  • We found in a DNA microarray analysis that the expression of THI genes increased 10- to 90-fold in response to thiamin deprivation, and likewise, the expression of THI2 and THI3 increased 17-fold and threefold, respectively [2].
  • In this yeast THI regulatory system acts mainly at the transcriptional level, thiamin pyrophosphate (TDP) seems to serve as a corepressor, and genetic studies have identified three positive regulatory factors (Thi2p, Thi3p and Pdc2p) [2].
  • In contrast to thiamine biosynthesis genes of other fungi that are completely suppressed by thiamine, THI1 and THI2 expression was not affected by the addition of thiamine to rust hyphae grown either in vitro or in planta [3].

Other interactions of THI2

  • While the Thi2, in conjunction with Thi3, seems to control expression of THI genes with respect to thiamine availability, the Pdc2 may link the ThDP demand to carbon source availability [4].


  1. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. Nosaka, K., Nishimura, H., Kawasaki, Y., Tsujihara, T., Iwashima, A. J. Biol. Chem. (1994) [Pubmed]
  2. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Nosaka, K., Onozuka, M., Konno, H., Kawasaki, Y., Nishimura, H., Sano, M., Akaji, K. Mol. Microbiol. (2005) [Pubmed]
  3. High level activation of vitamin B1 biosynthesis genes in haustoria of the rust fungus Uromyces fabae. Sohn, J., Voegele, R.T., Mendgen, K., Hahn, M. Mol. Plant Microbe Interact. (2000) [Pubmed]
  4. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita, D., Hohmann, S. Mol. Genet. Genomics (2006) [Pubmed]
WikiGenes - Universities