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Gene Review

THI3  -  branched-chain-2-oxoacid decarboxylase THI3

Saccharomyces cerevisiae S288c

Synonyms: KID1, Keto isocaproate decarboxylase KID1, Thiamine metabolism regulatory protein THI3, YDL080C
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High impact information on THI3


Biological context of THI3


Other interactions of THI3

  • While the Thi2, in conjunction with Thi3, seems to control expression of THI genes with respect to thiamine availability, the Pdc2 may link the ThDP demand to carbon source availability [5].


  1. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo, F., Nosaka, K., Ogata, M., Iwashima, A., Nishimura, H. J. Biol. Chem. (1997) [Pubmed]
  2. Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae. Nosaka, K., Kaneko, Y., Nishimura, H., Iwashima, A. J. Biol. Chem. (1993) [Pubmed]
  3. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Nosaka, K., Onozuka, M., Konno, H., Kawasaki, Y., Nishimura, H., Sano, M., Akaji, K. Mol. Microbiol. (2005) [Pubmed]
  4. A positive regulatory gene, THI3, is required for thiamine metabolism in Saccharomyces cerevisiae. Nishimura, H., Kawasaki, Y., Kaneko, Y., Nosaka, K., Iwashima, A. J. Bacteriol. (1992) [Pubmed]
  5. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita, D., Hohmann, S. Mol. Genet. Genomics (2006) [Pubmed]
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