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SOH1  -  Soh1p

Saccharomyces cerevisiae S288c

Synonyms: G2864, Hpr1 suppressor protein 1, MED31, Mediator complex subunit 31, Mediator of RNA polymerase II transcription subunit 31, ...
 
 
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High impact information on SOH1

  • Bioinformatic analysis traces the Soh1/MED31 family of Mediator subunits to the point of major eukaryotic divergence, before the appearance of the canonical heptapeptide repeat structure of the RNA polymerase II C-terminal domain [1].
  • Because mutations in SOH1, RPB2 and SUA7 suppress the hyperrecombination phenotype of hpr1 mutants, this suggests a link between recombination in direct repeats and transcription [2].
  • Interestingly, SOH1 not only interacts with factors involved in DNA repair, but transcription as well [2].
  • The soh1, soh2 and soh4 mutants were isolated as suppressors of the temperature-dependent growth of the hyperrecombination mutant hpr1 of Saccharomyces cerevisiae [2].
  • The Soh1 protein interacts with a DNA repair protein, Rad5p, in a two-hybrid system assay [2].
 

Associations of SOH1 with chemical compounds

 

Analytical, diagnostic and therapeutic context of SOH1

References

  1. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. Linder, T., Gustafsson, C.M. J. Biol. Chem. (2004) [Pubmed]
  2. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae. Fan, H.Y., Cheng, K.K., Klein, H.L. Genetics (1996) [Pubmed]
  3. A high resolution protein interaction map of the yeast Mediator complex. Guglielmi, B., van Berkum, N.L., Klapholz, B., Bijma, T., Boube, M., Boschiero, C., Bourbon, H.M., Holstege, F.C., Werner, M. Nucleic Acids Res. (2004) [Pubmed]
 
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