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Gene Review

PUF4  -  Puf4p

Saccharomyces cerevisiae S288c

Synonyms: Pumilio homology domain family member 4, YGL014W, YGL023
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High impact information on PUF4

  • Furthermore, this relocalization is dependent on both UTH4 a novel yeast gene that extends life span, and its homologue YGL023 [1].
  • We identified and computationally characterized the binding sites for six mRNA stability regulators in Saccharomyces cerevisiae, which include two members of the Pumilio-homology domain (Puf) family of RNA-binding proteins, Puf3p and Puf4p [2].
  • Pan2p and Puf4p also contributed to the degradation rate of these mRNAs following transcriptional shutoff, while Pub1p preferentially stabilized transcripts encoding ribosomal proteins [3].
  • Deletions in SSD1 and PUF4, potential alternative regulators of cell integrity, also exhibit phenotypes [4].
  • Thus, these Ime4 and Puf4 proteins play complementary roles to rescue the defects in Deltampt5 Deltasir cells [5].

Associations of PUF4 with chemical compounds

  • Furthermore, the suppression of the HU sensitivity depended on PUF4, another Puf-family gene, and overexpression of PUF4 suppressed only the HU sensitivity of Deltampt5 [5].

Other interactions of PUF4

  • We identified distinct sequence motifs in the 3'-untranslated regions of the mRNAs bound by Puf3p, Puf4p, and Puf5p [6].


  1. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Kennedy, B.K., Gotta, M., Sinclair, D.A., Mills, K., McNabb, D.S., Murthy, M., Pak, S.M., Laroche, T., Gasser, S.M., Guarente, L. Cell (1997) [Pubmed]
  2. Profiling condition-specific, genome-wide regulation of mRNA stability in yeast. Foat, B.C., Houshmandi, S.S., Olivas, W.M., Bussemaker, H.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Grigull, J., Mnaimneh, S., Pootoolal, J., Robinson, M.D., Hughes, T.R. Mol. Cell. Biol. (2004) [Pubmed]
  4. Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans. Gerik, K.J., Donlin, M.J., Soto, C.E., Banks, A.M., Banks, I.R., Maligie, M.A., Selitrennikoff, C.P., Lodge, J.K. Mol. Microbiol. (2005) [Pubmed]
  5. Suppressor analysis of the mpt5/htr1/uth4/puf5 deletion in Saccharomyces cerevisiae. Ohkuni, K., Kikuchi, Y., Hara, K., Taneda, T., Hayashi, N., Kikuchi, A. Mol. Genet. Genomics (2006) [Pubmed]
  6. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. Gerber, A.P., Herschlag, D., Brown, P.O. PLoS Biol. (2004) [Pubmed]
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