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Gene Review

IME4  -  Ime4p

Saccharomyces cerevisiae S288c

Synonyms: G1337, N6-adenosine-methyltransferase IME4, SPO8, YGL192W
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High impact information on IME4


Biological context of IME4

  • This observation led to the hypothesis that yeast sporulation may be dependent upon methylation of yeast mRNA, mediated by Ime4p [3].
  • Moreover, single amino acid substitutions in the putative catalytic residues of Ime4p lead to severe sporulation defects in a strain whose sporulation ability is completely dependent on this protein [3].

Associations of IME4 with chemical compounds

  • We found that a diploid-specific IME4 gene encoding an RNA-modifying protein was responsible for the suppression of the temperature sensitivity, but not of the HU sensitivity [4].
  • Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene [3].

Other interactions of IME4

  • Under identical experimental conditions, expression of the MCKI and IME4 genes (which promote sporulation but do not require Ime1p for expression) was not affected [5].
  • Thus, these Ime4 and Puf4 proteins play complementary roles to rescue the defects in Deltampt5 Deltasir cells [4].
  • These two genes are (with SPO7, SPO8, and SPO9) among the earliest identified in the sporulation pathway and may interact directly with the positive and negative regulators RME and IME [6].


  1. IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae. Shah, J.C., Clancy, M.J. Mol. Cell. Biol. (1992) [Pubmed]
  2. Molecular characterization of the yeast meiotic regulatory gene RIM1. Su, S.S., Mitchell, A.P. Nucleic Acids Res. (1993) [Pubmed]
  3. Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. Clancy, M.J., Shambaugh, M.E., Timpte, C.S., Bokar, J.A. Nucleic Acids Res. (2002) [Pubmed]
  4. Suppressor analysis of the mpt5/htr1/uth4/puf5 deletion in Saccharomyces cerevisiae. Ohkuni, K., Kikuchi, Y., Hara, K., Taneda, T., Hayashi, N., Kikuchi, A. Mol. Genet. Genomics (2006) [Pubmed]
  5. The S. cerevisiae nitrogen starvation-induced Yvh1p and Ptp2p phosphatases play a role in control of sporulation. Park, H.D., Beeser, A.E., Clancy, M.J., Cooper, T.G. Yeast (1996) [Pubmed]
  6. Identification and characterization of mutations affecting sporulation in Saccharomyces cerevisiae. Smith, L.M., Robbins, L.G., Kennedy, A., Magee, P.T. Genetics (1988) [Pubmed]
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