Gene Review:
UPF3 - Upf3p
Saccharomyces cerevisiae S288c
Synonyms:
Nonsense-mediated mRNA decay protein 3, SUA6, SUP112, Up-frameshift suppressor 3, YGR072W
- A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence. Shirley, R.L., Lelivelt, M.J., Schenkman, L.R., Dahlseid, J.N., Culbertson, M.R. J. Cell. Sci. (1998)
- Targeting of aberrant mRNAs to cytoplasmic processing bodies. Sheth, U., Parker, R. Cell (2006)
- Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Cui, Y., Hagan, K.W., Zhang, S., Peltz, S.W. Genes Dev. (1995)
- Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Lee, B.S., Culbertson, M.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast. Shirley, R.L., Ford, A.S., Richards, M.R., Albertini, M., Culbertson, M.R. Genetics (2002)
- Suppression of termination mutations caused by defects of the NMD machinery in Saccharomyces cerevisiae. Ono, B., Yoshida, R., Kamiya, K., Sugimoto, T. Genes Genet. Syst. (2005)
- Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells. Enomoto, S., Glowczewski, L., Lew-Smith, J., Berman, J.G. Mol. Cell. Biol. (2004)
- Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs. He, F., Jacobson, A. Mol. Cell. Biol. (2001)