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Gene Review:

TIM13 - Tim13p

Saccharomyces cerevisiae S288c

Synonyms: G7157, Mitochondrial import inner membrane translocase subunit TIM13, YGR181W

Hoppins, S.C. et al., Lutz, T. et al., Terziyska, N. et al., Truscott, K.N. et al.

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High impact information on TIM13

Mutagenesis of the cysteine residues or pretreatment with metal chelators interfered with folding of Tim13 in vitro and impaired its import into mitochondria [1].
Upon depletion of metal ions or modification of cysteine residues, imported Tim13 diffused back out of the IMS [1].
Import of Tim13 did not depend on the membrane potential or ATP hydrolysis [1].
The nonessential Tim8-Tim13 complex of the intermembrane space is not involved in the transfer of AAC across the outer membrane [2].
Tim23 import intermediates could also be cross-linked to the complex, suggesting a dual role for the Tim8-Tim13 intermembrane space complex in the import of proteins found in both the outer and inner mitochondrial membranes [3].

Biological context of TIM13

As in yeast, the N. crassa Tim23 precursor was imported inefficiently into mitochondria lacking the Tim8-Tim13 complex when the membrane potential was reduced [3].

Anatomical context of TIM13

The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes [3].

Physical interactions of TIM13

Furthermore, Mia40 directly interacts with newly imported Tim13 protein [4].

Other interactions of TIM13

Cross-linking studies showed that the Tom40 precursor contacts the Tim8-Tim13 complex [3].
In cells lacking Mia40, the endogenous levels of Tim13 and other metal-binding IMS proteins are strongly reduced due to the impaired import of these proteins [4].

References

Import of small Tim proteins into the mitochondrial intermembrane space. Lutz, T., Neupert, W., Herrmann, J.M. EMBO J. (2003) [Pubmed]
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Truscott, K.N., Wiedemann, N., Rehling, P., Müller, H., Meisinger, C., Pfanner, N., Guiard, B. Mol. Cell. Biol. (2002) [Pubmed]
The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes. Hoppins, S.C., Nargang, F.E. J. Biol. Chem. (2004) [Pubmed]
Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska, N., Lutz, T., Kozany, C., Mokranjac, D., Mesecke, N., Neupert, W., Herrmann, J.M., Hell, K. FEBS Lett. (2005) [Pubmed]

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AGOS_AAL144C	Ashbya gossypii ATCC 10895
KLLA0F15312g	Kluyveromyces lactis NRRL Y-1140

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