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MIA40  -  Mia40p

Saccharomyces cerevisiae S288c

Synonyms: FMP15, Mitochondrial import inner membrane translocase TIM40, Mitochondrial intermembrane space import and assembly protein 40, TIM40, YKL195W
 
 
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High impact information on MIA40

 

Associations of MIA40 with chemical compounds

  • In particular, the disulfide bond formed by the third and sixth cysteine residues apparently supports a conformation crucial for the function of Mia40 [5].
 

Biological context of MIA40

  • Tim40 is essential for yeast cell growth, and its function in vivo requires six conserved Cys residues but not anchoring of the protein to the inner membrane by its N-terminal hydrophobic segment [4].
  • The biogenesis of small IMS proteins requires an essential mitochondrial IMS import and assembly protein, termed Mia40 [6].
 

Anatomical context of MIA40

  • Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions [7].
 

Physical interactions of MIA40

  • Furthermore, Mia40 directly interacts with newly imported Tim13 protein [7].
 

Other interactions of MIA40

  • In cells lacking Mia40, the endogenous levels of Tim13 and other metal-binding IMS proteins are strongly reduced due to the impaired import of these proteins [7].
  • Depletion of Erv1 or conditions reducing Mia40 prevent protein import [2].

References

  1. A disulfide relay system in mitochondria. Tokatlidis, K. Cell (2005) [Pubmed]
  2. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Mesecke, N., Terziyska, N., Kozany, C., Baumann, F., Neupert, W., Hell, K., Herrmann, J.M. Cell (2005) [Pubmed]
  3. Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Guiard, B., Meisinger, C., Pfanner, N. EMBO J. (2004) [Pubmed]
  4. Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space. Naoé, M., Ohwa, Y., Ishikawa, D., Ohshima, C., Nishikawa, S., Yamamoto, H., Endo, T. J. Biol. Chem. (2004) [Pubmed]
  5. Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria. Terziyska, N., Grumbt, B., Kozany, C., Hell, K. J. Biol. Chem. (2009) [Pubmed]
  6. The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. Rissler, M., Wiedemann, N., Pfannschmidt, S., Gabriel, K., Guiard, B., Pfanner, N., Chacinska, A. J. Mol. Biol. (2005) [Pubmed]
  7. Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska, N., Lutz, T., Kozany, C., Mokranjac, D., Mesecke, N., Neupert, W., Herrmann, J.M., Hell, K. FEBS Lett. (2005) [Pubmed]
 
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