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Gene Review

PEX21  -  Pex21p

Saccharomyces cerevisiae S288c

Synonyms: G8593, Peroxin-21, Peroxisomal membrane protein PEX21, YGR239C
 
 
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High impact information on PEX21

  • Previously, we have reported that ScPex7p resides predominantly in the peroxisomal matrix, suggesting that it may function as a highly unusual intraorganellar import receptor, and the data presented in this paper identify Pex18p and Pex21p as key components in the targeting of Pex7p to peroxisomes [1].
  • Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway [1].
  • In addition, in the genomes of Saccharomyces cerevisiae and Candida glabrata, several PEX genes appear to have been duplicated, exemplified by the presence of paralogs of the peroxins Pex5p and Pex21p, which were absent in other organisms [2].
  • Furthermore, purified Pex21p acts as an activator of yeast seryl-tRNA synthetase in aminoacylation in vitro, revealing the functional significance of the Pex21p-SerRS interaction [3].
  • Pex21p is a protein involved in the peroxisome biogenesis [Purdue, P.E., Yang, X. and Lazarow, P.B., J. Cell Biol. 143 (1998) 1859-1869] [3].
 

Biological context of PEX21

 

Associations of PEX21 with chemical compounds

 

Other interactions of PEX21

References

  1. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. Purdue, P.E., Yang, X., Lazarow, P.B. J. Cell Biol. (1998) [Pubmed]
  2. PEX Genes in Fungal Genomes: Common, Rare or Redundant. Kiel, J.A., Veenhuis, M., van der Klei, I.J. Traffic (2006) [Pubmed]
  3. Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase. Rocak, S., Landeka, I., Weygand-Durasevic, I. FEMS Microbiol. Lett. (2002) [Pubmed]
  4. Pex18p is constitutively degraded during peroxisome biogenesis. Purdue, P.E., Lazarow, P.B. J. Biol. Chem. (2001) [Pubmed]
  5. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Stein, K., Schell-Steven, A., Erdmann, R., Rottensteiner, H. Mol. Cell. Biol. (2002) [Pubmed]
 
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