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MTR4  -  ATP-dependent RNA helicase MTR4

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent RNA helicase DOB1, DOB1, J1158, YJL050W, mRNA transport regulator MTR4
 
 
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High impact information on MTR4

  • Long extended read-through transcripts generated in rna14.1 and rna15.2 strains are greatly stabilized by depletion of Rrp41p, a core component of the exosome complex or the RNA helicase Dob1p/Mtr4p [1].
  • Critical residues of Mtr4p, including the mtr4-1 point mutation, have been identified [2].
  • As a possible ortholog of the yeast exosome-associated protein, Dob1p (Mtr4p), HUA ENHANCER2 may affect floral organ spacing and identity through the regulation of protein synthesis or mRNA degradation [3].
  • Recent analyses have shown that the activity of the yeast nuclear exosome is stimulated by the Trf4p-Air1/2p-Mtr4p polyadenylation (TRAMP) complex [4].
  • Trf5p co-purified with Mtr4p and Air1p, indicating that it forms a complex, designated TRAMP5, that has functions that partially overlap with the TRAMP complex [4].
 

Anatomical context of MTR4

  • DOB1 can interact with a second ATP-binding module mutant of NVL2, which shows a dominant negative effect on ribosome synthesis [5].
 

Other interactions of MTR4

  • Inhibition of 5.8S rRNA maturation in gsp1 was rescued by overexpression of nuclear exosome components Dis3p, Rrp4p, and Mtr4p, but not by a cytoplasmic exosome component, Ski2p [6].

References

  1. Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Torchet, C., Bousquet-Antonelli, C., Milligan, L., Thompson, E., Kufel, J., Tollervey, D. Mol. Cell (2002) [Pubmed]
  2. A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA. Liang, S., Hitomi, M., Hu, Y.H., Liu, Y., Tartakoff, A.M. Mol. Cell. Biol. (1996) [Pubmed]
  3. HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis. Western, T.L., Cheng, Y., Liu, J., Chen, X. Development (2002) [Pubmed]
  4. Yeast Trf5p is a nuclear poly(A) polymerase. Houseley, J., Tollervey, D. EMBO Rep. (2006) [Pubmed]
  5. The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1. Nagahama, M., Yamazoe, T., Hara, Y., Tani, K., Tsuji, A., Tagaya, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome. Suzuki, N., Noguchi, E., Nakashima, N., Oki, M., Ohba, T., Tartakoff, A., Ohishi, M., Nishimoto, T. Genetics (2001) [Pubmed]
 
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