High impact information on AIR1

• Surprisingly, however, RNAs originating from these regions are rapidly degraded by the combined action of the exosome and a new poly(A) polymerase activity that is defined by the Trf4 protein and one of two RNA binding proteins, Air1p or Air2p [1].
• Bipolar spindles are formed in the absence of AIR-1, but they appear to be disorganized and are nucleated by abnormal-looking centrosomes [2].
• A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos [2].
• Disruption of AIR-1 protein expression in C. elegans embryos results in severe aneuploidy and embryonic lethality [2].
• Our data suggests AIR-1 plays a role in P-granule segregation and the association of the germline factor PIE-1 with centrosomes [2].

Biological context of AIR1

• Although single disruption of either gene gave no effect on the cell growth, cells lacking Air1p and Air2p grew at an extremely slow rate with accumulated poly(A)(+) RNA in the nucleus [3].
• Thus, Air1p and Air2p may affect mRNA transport by regulating the arginine methylation state of heterogeneous nuclear ribonucleoproteins [3].
• In addition to its requirement during mitosis, AIR-1 may regulate microtubule-based developmental processes as well [2].

Regulatory relationships of AIR1

• Overexpression of Air1p repressed the Hmt1p-dependent growth of cells [3].

Other interactions of AIR1

• Since homology searches indicate that the YDL175 gene product has significant identity (45%) with Air1p, we designated the gene AIR2 [3].
• Trf5p co-purified with Mtr4p and Air1p, indicating that it forms a complex, designated TRAMP5, that has functions that partially overlap with the TRAMP complex [4].

References