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Gene Review

TRF5  -  non-canonical poly(A) polymerase TRF5

Saccharomyces cerevisiae S288c

Synonyms: N0440, Poly(A) RNA polymerase protein 1, Topoisomerase 1-related protein TRF5, YNL299W
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High impact information on TRF5


Biological context of TRF5


Other interactions of TRF5

  • Here we describe the isolation of a second member of the TRF4 gene family, TRF5 [3].


  1. Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Read, R.L., Martinho, R.G., Wang, S.W., Carr, A.M., Norbury, C.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Yeast Trf5p is a nuclear poly(A) polymerase. Houseley, J., Tollervey, D. EMBO Rep. (2006) [Pubmed]
  3. A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation. Castaño, I.B., Heath-Pagliuso, S., Sadoff, B.U., Fitzhugh, D.J., Christman, M.F. Nucleic Acids Res. (1996) [Pubmed]
  4. Contribution of Trf4/5 and the Nuclear Exosome to Genome Stability Through Regulation of Histone mRNA Levels in Saccharomyces cerevisiae. Reis, C.C., Campbell, J.L. Genetics (2007) [Pubmed]
  5. DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. Aravind, L., Koonin, E.V. Nucleic Acids Res. (1999) [Pubmed]
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