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Gene Review

MHP1  -  Mhp1p

Saccharomyces cerevisiae S288c

Synonyms: J1206, MAP-homologous protein 1, YJL042W
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High impact information on MHP1

  • In asynchronously growing cells that overexpress MHP1 from a multicopy plasmid, the length and number of cytoplasmic microtubules is increased and the proportion of mitotic cells is decreased, while haploid cells in which the expression of MHP1 has been silenced exhibit few microtubules [1].
  • The overexpression of an NH2-terminal deletion mutation of MHP1 results in an accumulation of large-budded cells with short spindles and disturbed nuclear migration [1].
  • MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function [1].
  • A second plasmid carried a portion of the MHP1 gene which has been reported to encode a microtubule-interacting protein (Irminger-Finger et al., 1996) [2].
  • Cells carrying the amino portion of MHP1 at multiple copy show a decrease in high molecular weight cell wall beta(1-6) glucans and were killer toxin resistant while a disruption strain was viable and killer toxin super-sensitive [2].

Biological context of MHP1

  • However, the overexpression of MHP1 did not alter the phenotypes of individual overexpression of a or beta-tubulin [3].
  • We demonstrate that overexpression of MHP1 in asynchronously growing yeast cultures leads to cell cycle arrest in G2 [3].

Anatomical context of MHP1


Other interactions of MHP1

  • The MHP1 gene product is a predicted 1398 amino acid protein and only approximately 80% of the amino portion of this protein is required for laminarinase resistance [2].

Analytical, diagnostic and therapeutic context of MHP1


  1. MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function. Irminger-Finger, I., Hurt, E., Roebuck, A., Collart, M.A., Edelstein, S.J. J. Cell Biol. (1996) [Pubmed]
  2. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Lai, M.H., Silverman, S.J., Gaughran, J.P., Kirsch, D.R. Yeast (1997) [Pubmed]
  3. Effect of microtubule-associated protein MHP1 on microtubule assembly and cell cycle progression in Saccharomyces cerevisiae. Irminger-Finger, I., Mathis, N. Cell Struct. Funct. (1998) [Pubmed]
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